FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023882694> ?p ?o ?g. }

• W2023882694 endingPage "109" @default.
• W2023882694 startingPage "99" @default.
• W2023882694 abstract "Sudden cardiovascular death is increased in chronic kidney disease (CKD). Experimental CKD models suggest that angiogenesis and nitric oxide (NO) inhibitors induce myocardial fibrosis and microvascular dropout thereby facilitating arrhythmogenesis. We undertook this study to characterize associations of CKD with human myocardial pathology, NO-related circulating angiogenesis inhibitors, and endothelial cell behavior.We compared heart (n=54) and serum (n=162) samples from individuals with and without CKD, and assessed effects of serum on human coronary artery endothelial cells (HCAECs) in vitro. Left ventricular fibrosis and capillary density were quantified in post-mortem samples. Endothelial to mesenchymal transition (EndMT) was assessed by immunostaining of post-mortem samples and RNA expression in heart tissue obtained during cardiac surgery. Circulating asymmetric dimethylarginine (ADMA), endostatin (END), angiopoietin-2 (ANG), and thrombospondin-2 (TSP) were measured, and the effect of these factors and of subject serum on proliferation, apoptosis, and EndMT of HCAEC was analyzed.Cardiac fibrosis increased 12% and 77% in stage 3-4 CKD and ESRD and microvascular density decreased 12% and 16% vs. preserved renal function. EndMT-derived fibroblast proportion was 17% higher in stage 3-4 CKD and ESRD (P trend = 0.02). ADMA, ANG, TSP, and END concentrations increased in CKD. Both individual factors and CKD serum increased HCAEC apoptosis (P=0.02), decreased proliferation (P=0.03), and induced EndMT.CKD is associated with an increase in circulating angiogenesis and NO inhibitors, which impact proliferation and apoptosis of cardiac endothelial cells and promote EndMT, leading to cardiac fibrosis and capillary rarefaction. These processes may play key roles in CKD-associated CV disease." @default.
• W2023882694 created "2016-06-24" @default.
• W2023882694 creator A5004654560 @default.
• W2023882694 creator A5016675086 @default.
• W2023882694 creator A5019306613 @default.
• W2023882694 creator A5025662877 @default.
• W2023882694 creator A5040449530 @default.
• W2023882694 creator A5041974767 @default.
• W2023882694 creator A5042273614 @default.
• W2023882694 creator A5068118468 @default.
• W2023882694 creator A5076777692 @default.
• W2023882694 creator A5088394454 @default.
• W2023882694 date "2014-09-01" @default.
• W2023882694 modified "2023-09-30" @default.
• W2023882694 title "Increased concentration of circulating angiogenesis and nitric oxide inhibitors induces endothelial to mesenchymal transition and myocardial fibrosis in patients with chronic kidney disease" @default.
• W2023882694 cites W1968431199 @default.
• W2023882694 cites W1980813714 @default.
• W2023882694 cites W2003552873 @default.
• W2023882694 cites W2004433500 @default.
• W2023882694 cites W2005673278 @default.
• W2023882694 cites W2017813592 @default.
• W2023882694 cites W2019663114 @default.
• W2023882694 cites W2023213297 @default.
• W2023882694 cites W2038218691 @default.
• W2023882694 cites W2041116703 @default.
• W2023882694 cites W2049428559 @default.
• W2023882694 cites W2061718082 @default.
• W2023882694 cites W2063503252 @default.
• W2023882694 cites W2065569295 @default.
• W2023882694 cites W2073742622 @default.
• W2023882694 cites W2073789348 @default.
• W2023882694 cites W2081518693 @default.
• W2023882694 cites W2082012778 @default.
• W2023882694 cites W2086100170 @default.
• W2023882694 cites W2089550304 @default.
• W2023882694 cites W2101447446 @default.
• W2023882694 cites W2109921861 @default.
• W2023882694 cites W2113065121 @default.
• W2023882694 cites W2118621310 @default.
• W2023882694 cites W2120357999 @default.
• W2023882694 cites W2136701967 @default.
• W2023882694 cites W2145632027 @default.
• W2023882694 cites W2148531805 @default.
• W2023882694 cites W2161918376 @default.
• W2023882694 doi "https://doi.org/10.1016/j.ijcard.2014.06.062" @default.
• W2023882694 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4161362" @default.
• W2023882694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25049013" @default.
• W2023882694 hasPublicationYear "2014" @default.
• W2023882694 type Work @default.
• W2023882694 sameAs 2023882694 @default.
• W2023882694 citedByCount "86" @default.
• W2023882694 countsByYear W20238826942015 @default.
• W2023882694 countsByYear W20238826942016 @default.
• W2023882694 countsByYear W20238826942017 @default.
• W2023882694 countsByYear W20238826942018 @default.
• W2023882694 countsByYear W20238826942019 @default.
• W2023882694 countsByYear W20238826942020 @default.
• W2023882694 countsByYear W20238826942021 @default.
• W2023882694 countsByYear W20238826942022 @default.
• W2023882694 countsByYear W20238826942023 @default.
• W2023882694 crossrefType "journal-article" @default.
• W2023882694 hasAuthorship W2023882694A5004654560 @default.
• W2023882694 hasAuthorship W2023882694A5016675086 @default.
• W2023882694 hasAuthorship W2023882694A5019306613 @default.
• W2023882694 hasAuthorship W2023882694A5025662877 @default.
• W2023882694 hasAuthorship W2023882694A5040449530 @default.
• W2023882694 hasAuthorship W2023882694A5041974767 @default.
• W2023882694 hasAuthorship W2023882694A5042273614 @default.
• W2023882694 hasAuthorship W2023882694A5068118468 @default.
• W2023882694 hasAuthorship W2023882694A5076777692 @default.
• W2023882694 hasAuthorship W2023882694A5088394454 @default.
• W2023882694 hasBestOaLocation W20238826942 @default.
• W2023882694 hasConcept C126322002 @default.
• W2023882694 hasConcept C134018914 @default.
• W2023882694 hasConcept C164705383 @default.
• W2023882694 hasConcept C2777420927 @default.
• W2023882694 hasConcept C2778653478 @default.
• W2023882694 hasConcept C2780394083 @default.
• W2023882694 hasConcept C2780559512 @default.
• W2023882694 hasConcept C3018763269 @default.
• W2023882694 hasConcept C519581460 @default.
• W2023882694 hasConcept C71924100 @default.
• W2023882694 hasConceptScore W2023882694C126322002 @default.
• W2023882694 hasConceptScore W2023882694C134018914 @default.
• W2023882694 hasConceptScore W2023882694C164705383 @default.
• W2023882694 hasConceptScore W2023882694C2777420927 @default.
• W2023882694 hasConceptScore W2023882694C2778653478 @default.
• W2023882694 hasConceptScore W2023882694C2780394083 @default.
• W2023882694 hasConceptScore W2023882694C2780559512 @default.
• W2023882694 hasConceptScore W2023882694C3018763269 @default.
• W2023882694 hasConceptScore W2023882694C519581460 @default.
• W2023882694 hasConceptScore W2023882694C71924100 @default.
• W2023882694 hasIssue "1" @default.
• W2023882694 hasLocation W20238826941 @default.
• W2023882694 hasLocation W20238826942 @default.
• W2023882694 hasLocation W20238826943 @default.
• W2023882694 hasLocation W20238826944 @default.
• W2023882694 hasOpenAccess W2023882694 @default.

• next