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• W2023883010 abstract "The human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In addition, increased incidences of infectious diseases, autoimmune diseases, chronic inflammatory diseases and virus-associated malignancies are observed in HTLV-1 carriers. HTLV-1 infection causes the continuous activation and clonal expansion of T cells. The levels of regulatory T cells and na?ve T-cells are decreased in the peripheral blood of asymptomatic carriers. Spontaneous proliferation of peripheral blood mononuclear cells and subclinical deficiencies in both type 1 and type 2 immunity are also observed. It is possible that the immune system imbalances seen in HTLV-1 infection account for the disease manifestations described above, although the precise mechanism remains unclear." @default.
• W2023883010 created "2016-06-24" @default.
• W2023883010 creator A5049434794 @default.
• W2023883010 date "2010-01-01" @default.
• W2023883010 modified "2023-10-09" @default.
• W2023883010 title "Natural history of human T-lymphotropic virus type 1 infection and immune system imbalances" @default.
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• W2023883010 doi "https://doi.org/10.2492/inflammregen.30.103" @default.
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