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- W2023883011 abstract "Abstract The thermal degradation of alkaline electron transfer particles and a respiratory chain reconstituted from simple enzyme complexes has been studied. It is shown that the reconstituted system loses its NADH oxidase activity rapidly and irreversibly at 38°. Electron transfer particles are also readily inactivated, but their NADH oxidase activity is restored completely after the addition of NADH under aerobic conditions. The NADH: cytochrome c oxidoreductase activity of submitochondrial particles undergoes similar changes, whereas the NADH: ferricyanide oxidoreductase and cytochrome oxidase activities do not change at all. Heating electron transfer particles results in a sharp drop in the steady-state levels of reduced cytochromes b, c(+c1), and aa3 at 6°, with NADH as the substrate. These results mean that one of the thermolabile electron transfer particles sites precedes cytochrome b in the respiratory chain. Preheated electron transfer particles are more sensitive to the action of chymotrypsin and potassium oleate than are the intact particles under the same conditions. Oleate prevents reactivation and causes substantial changes in the steady-state levels of reduced cytochromes in the preheated particles. Reactivation is accompanied by an increase in resistance of the particles to oleate and chymotrypsin. These observations suggest that the structure of electron transfer particles becomes slightly looser on heating, and is restored on reactivation. To reactivate the NADH oxidase system of submitochondrial particles NADH and oxygen are needed. Zn2+ inhibits electron transfer and thus prevents reactivation. Incubation of preheated particles with an excess of NADH and exogenous oxidized cytochrome c under anaerobic conditions does not result in complete recovery of NADH oxidase activity. Taking into account these results it must be concluded that reactivation is related to electron transfer through the entire NADH oxidase system, including cytochrome oxidase." @default.
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- W2023883011 title "Comparative study of thermal degradation of electron transfer particles and reconstituted respiratory chain. Relation of electron transfer to reactivation of submitochondrial particles" @default.
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- W2023883011 doi "https://doi.org/10.1016/0005-2728(70)90127-1" @default.
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