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• W2023885526 abstract "In general, vascular contributions to the in vivo magnetic resonance (MR) brain spectrum are too small to be relevant. In cerebral uptake studies, however, vascular contributions may constitute a major confounder. MR visibility of vascular Phe was investigated by recording localized spectra from fully oxygenated and well-mixed whole blood. Blood Phe levels determined by MR spectroscopy (MRS) and ion-exchange chromatography showed excellent correlation. In addition, effects of blood flow were shown to have a small effect on signal amplitude with the MRS methodology used. Hence, blood Phe is almost completely MR visible at 1.5 T, even though it is severely broadened at higher fields. Without appropriate correction, cerebral Phe influx in studies of brain Phe uptake in phenylketonuria patients or healthy subjects would appear to be faster and lead to higher levels. Similar effects are envisaged for studies of ethanol or glucose uptake across the blood-brain barrier." @default.
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• W2023885526 date "2005-01-01" @default.
• W2023885526 modified "2023-10-10" @default.
• W2023885526 title "Visibility of vascular phenylalanine in dynamic uptake studies in humans using magnetic resonance spectroscopy" @default.
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• W2023885526 doi "https://doi.org/10.1002/mrm.20539" @default.
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