FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023885809> ?p ?o ?g. }

• W2023885809 abstract "Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia, and microglia. In particular, cytokines and chemokines can affect cardinal cellular and molecular processes of hippocampal-dependent long-term memory consolidation including synaptic plasticity, synaptic scaling and neurogenesis. The chemokine, CX3CL1 (fractalkine), has been shown to modulate synaptic transmission and long-term potentiation (LTP) in the CA1 pyramidal cell layer of the hippocampus. Here, we confirm widespread expression of CX3CL1 on mature neurons in the adult rat hippocampus. We report an up-regulation in CX3CL1 protein expression in the CA1, CA3 and dentate gyrus (DG) of the rat hippocampus 2 h after spatial learning in the water maze task. Moreover, the same temporal increase in CX3CL1 was evident following LTP-inducing theta-burst stimulation in the DG. At physiologically relevant concentrations, CX3CL1 inhibited LTP maintenance in the DG. This attenuation in dentate LTP was lost in the presence of GABAA receptor/chloride channel antagonism. CX3CL1 also had opposing actions on glutamate-mediated rise in intracellular calcium in hippocampal organotypic slice cultures in the presence and absence of GABAA receptor/chloride channel blockade. Using primary dissociated hippocampal cultures, we established that CX3CL1 reduces glutamate-mediated intracellular calcium rises in both neurons and glia in a dose dependent manner. In conclusion, CX3CL1 is up-regulated in the hippocampus during a brief temporal window following spatial learning the purpose of which may be to regulate glutamate-mediated neurotransmission tone. Our data supports a possible role for this chemokine in the protective plasticity process of synaptic scaling." @default.
• W2023885809 created "2016-06-24" @default.
• W2023885809 creator A5004599362 @default.
• W2023885809 creator A5006269661 @default.
• W2023885809 creator A5028116006 @default.
• W2023885809 creator A5038017242 @default.
• W2023885809 creator A5050934210 @default.
• W2023885809 creator A5051206571 @default.
• W2023885809 creator A5064335735 @default.
• W2023885809 creator A5072577579 @default.
• W2023885809 creator A5077617925 @default.
• W2023885809 creator A5081630454 @default.
• W2023885809 date "2014-08-12" @default.
• W2023885809 modified "2023-10-14" @default.
• W2023885809 title "CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity" @default.
• W2023885809 cites W1480770914 @default.
• W2023885809 cites W1494960829 @default.
• W2023885809 cites W1600863966 @default.
• W2023885809 cites W1627446849 @default.
• W2023885809 cites W1765057352 @default.
• W2023885809 cites W1950124054 @default.
• W2023885809 cites W1963739260 @default.
• W2023885809 cites W1963806203 @default.
• W2023885809 cites W1963925096 @default.
• W2023885809 cites W1965666333 @default.
• W2023885809 cites W1967383957 @default.
• W2023885809 cites W1970891635 @default.
• W2023885809 cites W1973041420 @default.
• W2023885809 cites W1973187560 @default.
• W2023885809 cites W1973922157 @default.
• W2023885809 cites W1975164266 @default.
• W2023885809 cites W1977386271 @default.
• W2023885809 cites W1977463464 @default.
• W2023885809 cites W1986866315 @default.
• W2023885809 cites W1988461110 @default.
• W2023885809 cites W1989369404 @default.
• W2023885809 cites W1991338510 @default.
• W2023885809 cites W1994201230 @default.
• W2023885809 cites W1994254814 @default.
• W2023885809 cites W1996055705 @default.
• W2023885809 cites W1997422264 @default.
• W2023885809 cites W1999363307 @default.
• W2023885809 cites W2005804545 @default.
• W2023885809 cites W2005933589 @default.
• W2023885809 cites W2006166044 @default.
• W2023885809 cites W2006680088 @default.
• W2023885809 cites W2007287932 @default.
• W2023885809 cites W2007421151 @default.
• W2023885809 cites W2012785062 @default.
• W2023885809 cites W2012865678 @default.
• W2023885809 cites W2013803050 @default.
• W2023885809 cites W2015776364 @default.
• W2023885809 cites W2019013347 @default.
• W2023885809 cites W2029113383 @default.
• W2023885809 cites W2029766072 @default.
• W2023885809 cites W2032618901 @default.
• W2023885809 cites W2034054679 @default.
• W2023885809 cites W2038911997 @default.
• W2023885809 cites W2041680657 @default.
• W2023885809 cites W2043939614 @default.
• W2023885809 cites W2047535883 @default.
• W2023885809 cites W2049511526 @default.
• W2023885809 cites W2050066016 @default.
• W2023885809 cites W2050603503 @default.
• W2023885809 cites W2052193782 @default.
• W2023885809 cites W2056688527 @default.
• W2023885809 cites W2057839027 @default.
• W2023885809 cites W2058986539 @default.
• W2023885809 cites W2063620427 @default.
• W2023885809 cites W2068607362 @default.
• W2023885809 cites W2071832924 @default.
• W2023885809 cites W2078865976 @default.
• W2023885809 cites W2079054696 @default.
• W2023885809 cites W2079806280 @default.
• W2023885809 cites W2083283628 @default.
• W2023885809 cites W2084658248 @default.
• W2023885809 cites W2085487753 @default.
• W2023885809 cites W2085600478 @default.
• W2023885809 cites W2087736278 @default.
• W2023885809 cites W2092173310 @default.
• W2023885809 cites W2093106975 @default.
• W2023885809 cites W2094858611 @default.
• W2023885809 cites W2097503778 @default.
• W2023885809 cites W2097547448 @default.
• W2023885809 cites W2099005297 @default.
• W2023885809 cites W2104964311 @default.
• W2023885809 cites W2106903618 @default.
• W2023885809 cites W2107380054 @default.
• W2023885809 cites W2111748635 @default.
• W2023885809 cites W2113107925 @default.
• W2023885809 cites W2113971423 @default.
• W2023885809 cites W2115462216 @default.
• W2023885809 cites W2119368421 @default.
• W2023885809 cites W2122175586 @default.
• W2023885809 cites W2123366268 @default.
• W2023885809 cites W2126972955 @default.
• W2023885809 cites W2130044487 @default.
• W2023885809 cites W2130290319 @default.
• W2023885809 cites W2144117545 @default.
• W2023885809 cites W2144414931 @default.

• next