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• W2023890954 abstract "Small molecule fluorometric boron dipyrromethene probes were developed to bind hepatitis C virus-encoded NS5A protein and aid subcellular distribution studies. These molecules did not co-locate with NS5A, therefore alternative 'silent' azide reporters were used to obtain a more relevant picture of their distribution. Following pre-incubation with replicon cells, click chemistry was used to append a fluorophore to the azide that confirmed the co-localisation of the small molecule with the NS5A protein, thus providing greater insight into the antiviral mode of action of this chemotype.The online version of this article (doi:10.1007/s12154-010-0047-1) contains supplementary material, which is available to authorized users." @default.
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• W2023890954 date "2010-11-18" @default.
• W2023890954 modified "2023-09-23" @default.
• W2023890954 title "In-cell click labelling of small molecules to determine subcellular localisation" @default.
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• W2023890954 doi "https://doi.org/10.1007/s12154-010-0047-1" @default.
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