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- W2023891551 abstract "Erythrocyte macrocytosis is noted in patients taking valproate with serum levels > 100 μg/ml. We postulated valproate affects membrane structure directly by altering membrane phospholipids. Patients were selected from a chronic care facility, had known static encephalopathy, were generally healthy, and on valproate monotherapy. Red cells were obtained from three groups: macrocytic with serum levels > 100 μg/ml (Group 1), normocytic with serum levels < 100 μg/ml (Group 2), and controls (Group 3). Patients in Group 2 demonstrated the highest level of membrane phospholipid content. Patients in Group 1 demonstrated total phospholipid content lower than controls. Phospholipid analysis demonstrated higher sphingomyelin and significantly lower phosphatidylserine in Group 1 than in Groups 2 or 3. Phosphatidylcholine and phosphatidylethanolamine did not significantly differ among the three groups. Valproate appears to alter the membrane matrix directly by affecting total phosphatidylserine and sphingomyelin contents. This effect is serum-concentration-specific, occurring when levels are > 100 μg/ml. Macrocytosis may be reflective of this biochemical, concentration-specific effect." @default.
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- W2023891551 date "1993-01-01" @default.
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- W2023891551 title "Valproic-acid-induced alteration in red cell membranes" @default.
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- W2023891551 doi "https://doi.org/10.1016/s0896-6974(05)80100-8" @default.
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