FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023892306> ?p ?o ?g. }

• W2023892306 endingPage "439" @default.
• W2023892306 startingPage "423" @default.
• W2023892306 abstract "Renal ciliopathies are a leading cause of kidney failure, but their exact etiology is poorly understood. NEK8/NPHP9 is a ciliary kinase associated with two renal ciliopathies in humans and mice, nephronophthisis (NPHP) and polycystic kidney disease. Here, we identify NEK8 as a key effector of the ATR-mediated replication stress response. Cells lacking NEK8 form spontaneous DNA double-strand breaks (DSBs) that further accumulate when replication forks stall, and they exhibit reduced fork rates, unscheduled origin firing, and increased replication fork collapse. NEK8 suppresses DSB formation by limiting cyclin A-associated CDK activity. Strikingly, a mutation in NEK8 that is associated with renal ciliopathies affects its genome maintenance functions. Moreover, kidneys of NEK8 mutant mice accumulate DNA damage, and loss of NEK8 or replication stress similarly disrupts renal cell architecture in a 3D-culture system. Thus, NEK8 is a critical component of the DNA damage response that links replication stress with cystic kidney disorders." @default.
• W2023892306 created "2016-06-24" @default.
• W2023892306 creator A5012379493 @default.
• W2023892306 creator A5015553749 @default.
• W2023892306 creator A5026373488 @default.
• W2023892306 creator A5040640163 @default.
• W2023892306 creator A5041250587 @default.
• W2023892306 creator A5042581048 @default.
• W2023892306 creator A5045572039 @default.
• W2023892306 creator A5047539455 @default.
• W2023892306 creator A5049067576 @default.
• W2023892306 creator A5055924536 @default.
• W2023892306 creator A5088938368 @default.
• W2023892306 date "2013-08-01" @default.
• W2023892306 modified "2023-10-08" @default.
• W2023892306 title "NEK8 Links the ATR-Regulated Replication Stress Response and S Phase CDK Activity to Renal Ciliopathies" @default.
• W2023892306 cites W1967630574 @default.
• W2023892306 cites W1985225356 @default.
• W2023892306 cites W1991069902 @default.
• W2023892306 cites W1991585430 @default.
• W2023892306 cites W2009707750 @default.
• W2023892306 cites W2020679229 @default.
• W2023892306 cites W2022492842 @default.
• W2023892306 cites W2031203839 @default.
• W2023892306 cites W2035300822 @default.
• W2023892306 cites W2043660829 @default.
• W2023892306 cites W2045069136 @default.
• W2023892306 cites W2058402985 @default.
• W2023892306 cites W2059971436 @default.
• W2023892306 cites W2062544482 @default.
• W2023892306 cites W2063979868 @default.
• W2023892306 cites W2066906157 @default.
• W2023892306 cites W2077436902 @default.
• W2023892306 cites W2078940989 @default.
• W2023892306 cites W2082861064 @default.
• W2023892306 cites W2086255242 @default.
• W2023892306 cites W2089367277 @default.
• W2023892306 cites W2090861867 @default.
• W2023892306 cites W2093442957 @default.
• W2023892306 cites W2094941673 @default.
• W2023892306 cites W2101345103 @default.
• W2023892306 cites W2101930901 @default.
• W2023892306 cites W2105590267 @default.
• W2023892306 cites W2105592350 @default.
• W2023892306 cites W2105719362 @default.
• W2023892306 cites W2106905343 @default.
• W2023892306 cites W2109900084 @default.
• W2023892306 cites W2113325631 @default.
• W2023892306 cites W2116774827 @default.
• W2023892306 cites W2119449193 @default.
• W2023892306 cites W2128426508 @default.
• W2023892306 cites W2138779444 @default.
• W2023892306 cites W2139204366 @default.
• W2023892306 cites W2141662443 @default.
• W2023892306 cites W2144455387 @default.
• W2023892306 cites W2144515265 @default.
• W2023892306 cites W2146741358 @default.
• W2023892306 cites W2149058622 @default.
• W2023892306 cites W2161424144 @default.
• W2023892306 cites W2172164880 @default.
• W2023892306 cites W2332974930 @default.
• W2023892306 cites W4246217303 @default.
• W2023892306 doi "https://doi.org/10.1016/j.molcel.2013.08.006" @default.
• W2023892306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3790667" @default.
• W2023892306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23973373" @default.
• W2023892306 hasPublicationYear "2013" @default.
• W2023892306 type Work @default.
• W2023892306 sameAs 2023892306 @default.
• W2023892306 citedByCount "123" @default.
• W2023892306 countsByYear W20238923062013 @default.
• W2023892306 countsByYear W20238923062014 @default.
• W2023892306 countsByYear W20238923062015 @default.
• W2023892306 countsByYear W20238923062016 @default.
• W2023892306 countsByYear W20238923062017 @default.
• W2023892306 countsByYear W20238923062018 @default.
• W2023892306 countsByYear W20238923062019 @default.
• W2023892306 countsByYear W20238923062020 @default.
• W2023892306 countsByYear W20238923062021 @default.
• W2023892306 countsByYear W20238923062022 @default.
• W2023892306 countsByYear W20238923062023 @default.
• W2023892306 crossrefType "journal-article" @default.
• W2023892306 hasAuthorship W2023892306A5012379493 @default.
• W2023892306 hasAuthorship W2023892306A5015553749 @default.
• W2023892306 hasAuthorship W2023892306A5026373488 @default.
• W2023892306 hasAuthorship W2023892306A5040640163 @default.
• W2023892306 hasAuthorship W2023892306A5041250587 @default.
• W2023892306 hasAuthorship W2023892306A5042581048 @default.
• W2023892306 hasAuthorship W2023892306A5045572039 @default.
• W2023892306 hasAuthorship W2023892306A5047539455 @default.
• W2023892306 hasAuthorship W2023892306A5049067576 @default.
• W2023892306 hasAuthorship W2023892306A5055924536 @default.
• W2023892306 hasAuthorship W2023892306A5088938368 @default.
• W2023892306 hasBestOaLocation W20238923061 @default.
• W2023892306 hasConcept C100094513 @default.
• W2023892306 hasConcept C104317684 @default.
• W2023892306 hasConcept C127716648 @default.
• W2023892306 hasConcept C195267511 @default.
• W2023892306 hasConcept C2778215940 @default.

• next