FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023893413> ?p ?o ?g. }

• W2023893413 abstract "S49.1 Lymphoma cells were arrested in G1 phase of the cell cycle when treated with either 1 μM dexamethasone (Dex) or 0.5 mM N6, O2-dibutyryl cyclic adenosine 3′ :5′ -monophosphate (Bt2cAMP) plus 0.2 mM theophylline. However, the two agents had markedly different effects on aspects of polyamine and cyclic nucleotide metabolism within the arrested cells. Bt2cAMP had an early and pronounced inhibitory effect on ornithine decarboxylase (ODC) activity causing a decrease to 40% of control within 1 h. However, there was no significant inhibition of ODC activity in the Dex-treated cells until 4 h of exposure, at which time ODC activity was reduced to approximately 60% of the control value. Sadenosyl-L-methionine decarboxylase (SAMD) activity was reduced by both agents, Bt2cAMP having the more pronounced inhibitory effect. The activity of SAMD was reduced to 40% of control after 10 h of Dex, whereas Bt2cAMP reduced the activity to approximately 25% of control within 4 h. Intracellular polyamine pools were decreased rapidly in Dex-treated cells but not in those exposed to Bt2cAMP. Bt2cAMP decreased the amount of type I (PKI) and type II (PKII) cyclic AMP-dependent protein kinase (cAMP-PK) activity to 30% of control or less within 2 h. In contrast, Dex had very little effect on either PKI or PKII until 24 h, when cell viability was affected. The specific activity of both PKI and PKII remained significantly decreased in cells exposed to Bt2cAMP for 6 h and then resuspended in fresh medium. The rapid decrease in ODC activity in response to Bt2cAMP and the slow recovery after washout may be due to the marked decreases in total PKI and PKII activities. Dex, which had no effect on PKI and PKII specific activities, only slowly inhibited ODC activity and recovery of enzyme activity was rapid upon resuspension in fresh medium. These data further stress the importance of the maintenance of the cellular protein kinase pools in the regulation of the recovery time to growth inhibition in response to naturally occurring steroids and second messengers." @default.
• W2023893413 created "2016-06-24" @default.
• W2023893413 creator A5022413250 @default.
• W2023893413 creator A5043646240 @default.
• W2023893413 creator A5083184695 @default.
• W2023893413 date "1981-03-01" @default.
• W2023893413 modified "2023-09-25" @default.
• W2023893413 title "Effects of dexamethasone and dibutyryl cyclic AMP on polyamine synthesizing enzymes in mouse lymphoma cells" @default.
• W2023893413 cites W1575451294 @default.
• W2023893413 cites W1603214546 @default.
• W2023893413 cites W1974476063 @default.
• W2023893413 cites W1990460156 @default.
• W2023893413 cites W1995267161 @default.
• W2023893413 cites W2000445419 @default.
• W2023893413 cites W2013216313 @default.
• W2023893413 cites W2016811661 @default.
• W2023893413 cites W2017465717 @default.
• W2023893413 cites W2018118934 @default.
• W2023893413 cites W2025873735 @default.
• W2023893413 cites W2049448240 @default.
• W2023893413 cites W2057456583 @default.
• W2023893413 cites W2077678162 @default.
• W2023893413 cites W2081301723 @default.
• W2023893413 cites W2083921192 @default.
• W2023893413 cites W2085374716 @default.
• W2023893413 cites W2089692062 @default.
• W2023893413 cites W2091935700 @default.
• W2023893413 cites W2127720777 @default.
• W2023893413 cites W2141449078 @default.
• W2023893413 cites W2169790726 @default.
• W2023893413 cites W250178245 @default.
• W2023893413 cites W4301061322 @default.
• W2023893413 doi "https://doi.org/10.1002/jcp.1041060307" @default.
• W2023893413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6260822" @default.
• W2023893413 hasPublicationYear "1981" @default.
• W2023893413 type Work @default.
• W2023893413 sameAs 2023893413 @default.
• W2023893413 citedByCount "19" @default.
• W2023893413 crossrefType "journal-article" @default.
• W2023893413 hasAuthorship W2023893413A5022413250 @default.
• W2023893413 hasAuthorship W2023893413A5043646240 @default.
• W2023893413 hasAuthorship W2023893413A5083184695 @default.
• W2023893413 hasConcept C104317684 @default.
• W2023893413 hasConcept C121289238 @default.
• W2023893413 hasConcept C126322002 @default.
• W2023893413 hasConcept C134018914 @default.
• W2023893413 hasConcept C181199279 @default.
• W2023893413 hasConcept C2776991684 @default.
• W2023893413 hasConcept C2778095195 @default.
• W2023893413 hasConcept C2778524494 @default.
• W2023893413 hasConcept C2780115381 @default.
• W2023893413 hasConcept C512185932 @default.
• W2023893413 hasConcept C55493867 @default.
• W2023893413 hasConcept C71924100 @default.
• W2023893413 hasConcept C79879829 @default.
• W2023893413 hasConcept C86803240 @default.
• W2023893413 hasConceptScore W2023893413C104317684 @default.
• W2023893413 hasConceptScore W2023893413C121289238 @default.
• W2023893413 hasConceptScore W2023893413C126322002 @default.
• W2023893413 hasConceptScore W2023893413C134018914 @default.
• W2023893413 hasConceptScore W2023893413C181199279 @default.
• W2023893413 hasConceptScore W2023893413C2776991684 @default.
• W2023893413 hasConceptScore W2023893413C2778095195 @default.
• W2023893413 hasConceptScore W2023893413C2778524494 @default.
• W2023893413 hasConceptScore W2023893413C2780115381 @default.
• W2023893413 hasConceptScore W2023893413C512185932 @default.
• W2023893413 hasConceptScore W2023893413C55493867 @default.
• W2023893413 hasConceptScore W2023893413C71924100 @default.
• W2023893413 hasConceptScore W2023893413C79879829 @default.
• W2023893413 hasConceptScore W2023893413C86803240 @default.
• W2023893413 hasLocation W20238934131 @default.
• W2023893413 hasLocation W20238934132 @default.
• W2023893413 hasOpenAccess W2023893413 @default.
• W2023893413 hasPrimaryLocation W20238934131 @default.
• W2023893413 hasRelatedWork W1976485394 @default.
• W2023893413 hasRelatedWork W1977124608 @default.
• W2023893413 hasRelatedWork W1998040738 @default.
• W2023893413 hasRelatedWork W2011717172 @default.
• W2023893413 hasRelatedWork W2067693794 @default.
• W2023893413 hasRelatedWork W2077416684 @default.
• W2023893413 hasRelatedWork W2077925316 @default.
• W2023893413 hasRelatedWork W2106188246 @default.
• W2023893413 hasRelatedWork W2149867949 @default.
• W2023893413 hasRelatedWork W2153052119 @default.
• W2023893413 isParatext "false" @default.
• W2023893413 isRetracted "false" @default.
• W2023893413 magId "2023893413" @default.
• W2023893413 workType "article" @default.