FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023893988> ?p ?o ?g. }

• W2023893988 endingPage "337" @default.
• W2023893988 startingPage "337" @default.
• W2023893988 abstract "Depressed patients as a group have been found to excrete greater amounts of catecholamines (CAs) and metabolites than healthy control subjects, but these differences were not uniform for all metabolites. Patients may differ from controls in the metabolism and/or disposition of CAs. We analyzed the suggested metabolic-dispositional differences by determining 24-hour urine values for norepinephrine (NE), epinephrine (E), normetanephrine (NM), metanephrine (M), vanillylmandelic acid (VMA), and 3-methoxy-4-hydroxyphenylglycol (MHPG). For each subject, we calculated ratios of CAs or metabolites to an estimate of CA synthesis and determined ratios of CAs and metabolites to each other based on a precursor-product paradigm. The results indicate that as a group, patients have modestly but significantly greater CA synthesis rates than controls; patients excrete disproportionately more NE and E and disproportionately less MHPG relative to estimated CA synthesis, as well as other metabolites, than do controls; in contrast to NE, E, and MHPG, the increased NM, M, and VMA excretion rates by patients are proportional to each other as well as to the increase in CA synthesis; and the differences in NE, E, and metabolite excretion in the patients as a group are due principally to unipolar rather than bipolar depressives. The differences would be expected if patients, relative to controls, released more NE and E into the circulation. These data indicate the need to measure several CAs and metabolites when evaluating differences between groups since the significance of any given metabolite value needs to be examined in the context of total CA and metabolite production and excretion." @default.
• W2023893988 created "2016-06-24" @default.
• W2023893988 creator A5001430126 @default.
• W2023893988 creator A5007461261 @default.
• W2023893988 creator A5010655140 @default.
• W2023893988 creator A5016638745 @default.
• W2023893988 creator A5024517119 @default.
• W2023893988 creator A5028340004 @default.
• W2023893988 creator A5030674909 @default.
• W2023893988 creator A5052344963 @default.
• W2023893988 creator A5056539065 @default.
• W2023893988 creator A5075253580 @default.
• W2023893988 date "1987-04-01" @default.
• W2023893988 modified "2023-09-27" @default.
• W2023893988 title "Catecholamine Metabolism and Disposition in Healthy and Depressed Subjects" @default.
• W2023893988 cites W101329441 @default.
• W2023893988 cites W1963895082 @default.
• W2023893988 cites W1966025039 @default.
• W2023893988 cites W1968160865 @default.
• W2023893988 cites W1970539422 @default.
• W2023893988 cites W1974702488 @default.
• W2023893988 cites W1976084007 @default.
• W2023893988 cites W1976250706 @default.
• W2023893988 cites W1978306437 @default.
• W2023893988 cites W1987025877 @default.
• W2023893988 cites W1999303204 @default.
• W2023893988 cites W2008949594 @default.
• W2023893988 cites W2010767319 @default.
• W2023893988 cites W2014251025 @default.
• W2023893988 cites W2016486395 @default.
• W2023893988 cites W2023678826 @default.
• W2023893988 cites W2030998472 @default.
• W2023893988 cites W2033087298 @default.
• W2023893988 cites W2035865479 @default.
• W2023893988 cites W2045142234 @default.
• W2023893988 cites W2045695488 @default.
• W2023893988 cites W2049019626 @default.
• W2023893988 cites W2049165791 @default.
• W2023893988 cites W2057456998 @default.
• W2023893988 cites W2057924260 @default.
• W2023893988 cites W2059160527 @default.
• W2023893988 cites W2060355791 @default.
• W2023893988 cites W2063330352 @default.
• W2023893988 cites W2068032736 @default.
• W2023893988 cites W2071975563 @default.
• W2023893988 cites W2072219714 @default.
• W2023893988 cites W2072722488 @default.
• W2023893988 cites W2075083057 @default.
• W2023893988 cites W2077341567 @default.
• W2023893988 cites W2092636531 @default.
• W2023893988 cites W2099098635 @default.
• W2023893988 cites W2130336453 @default.
• W2023893988 cites W2150678635 @default.
• W2023893988 cites W2165616253 @default.
• W2023893988 cites W2202180915 @default.
• W2023893988 cites W2212704849 @default.
• W2023893988 cites W22149755 @default.
• W2023893988 cites W2223963879 @default.
• W2023893988 cites W2309980614 @default.
• W2023893988 cites W2334197937 @default.
• W2023893988 cites W2409790008 @default.
• W2023893988 cites W2412389455 @default.
• W2023893988 cites W2418174847 @default.
• W2023893988 cites W2438462928 @default.
• W2023893988 cites W2470611989 @default.
• W2023893988 cites W2470629651 @default.
• W2023893988 cites W2474750468 @default.
• W2023893988 cites W2477272751 @default.
• W2023893988 cites W2479053579 @default.
• W2023893988 cites W2522973505 @default.
• W2023893988 cites W60925079 @default.
• W2023893988 doi "https://doi.org/10.1001/archpsyc.1987.01800160041007" @default.
• W2023893988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3566456" @default.
• W2023893988 hasPublicationYear "1987" @default.
• W2023893988 type Work @default.
• W2023893988 sameAs 2023893988 @default.
• W2023893988 citedByCount "85" @default.
• W2023893988 countsByYear W20238939882012 @default.
• W2023893988 countsByYear W20238939882015 @default.
• W2023893988 countsByYear W20238939882020 @default.
• W2023893988 crossrefType "journal-article" @default.
• W2023893988 hasAuthorship W2023893988A5001430126 @default.
• W2023893988 hasAuthorship W2023893988A5007461261 @default.
• W2023893988 hasAuthorship W2023893988A5010655140 @default.
• W2023893988 hasAuthorship W2023893988A5016638745 @default.
• W2023893988 hasAuthorship W2023893988A5024517119 @default.
• W2023893988 hasAuthorship W2023893988A5028340004 @default.
• W2023893988 hasAuthorship W2023893988A5030674909 @default.
• W2023893988 hasAuthorship W2023893988A5052344963 @default.
• W2023893988 hasAuthorship W2023893988A5056539065 @default.
• W2023893988 hasAuthorship W2023893988A5075253580 @default.
• W2023893988 hasConcept C10146269 @default.
• W2023893988 hasConcept C126322002 @default.
• W2023893988 hasConcept C134018914 @default.
• W2023893988 hasConcept C151730666 @default.
• W2023893988 hasConcept C170493617 @default.
• W2023893988 hasConcept C185592680 @default.
• W2023893988 hasConcept C2775841634 @default.

• next