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• W2023894972 abstract "Recently our group identified in murine bone marrow (BM) and human cord blood (CB), a rare population of very small embryonic-like (VSEL) stem cells. We hypothesize that these cells are deposited during embryonic development in BM as a mobile pool of circulating pluripotent stem cells (PSC) that play a pivotal role in postnatal tissue turnover both of non-hematopoietic and hematopoietic tissues. During in vitro co-cultures with murine myoblastic C2C12 cells, VSELs form spheres that contain primitive stem cells. Cells isolated from these spheres may give rise to cells from all three germ layers when plated in tissue specific media. The number of murine VSELs and their ability to form spheres decreases with the age and is reduced in short-living murine strains. Thus, developmental deposition of VSELs in adult tissues may potentially play an underappreciated role in regulating the rejuvenation of senescent organs. We envision that the regenerative potential of these cells could be harnessed to decelerate aging processes." @default.
• W2023894972 created "2016-06-24" @default.
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• W2023894972 date "2009-01-01" @default.
• W2023894972 modified "2023-09-26" @default.
• W2023894972 title "Very small embryonic-like stem cells in adult tissues—Potential implications for aging" @default.
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• W2023894972 doi "https://doi.org/10.1016/j.mad.2008.02.003" @default.
• W2023894972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3164811" @default.
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