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• W2023896460 abstract "Based on the hypothesis that bone cements cause changes in the production of transforming growth factor-beta 1 (TGF-β1) by bone cells, the effects of four acrylic bone cements (Sulfix-60, CMW 1, CMW 2 and CMW 3) were examined using the osteoblast-like cell line MG63. The extracts in MEM of the cements were tested, following 1 h- and 7 day-curing. MG63 cells seldom expressed mRNA specific for TGF-β1 in basal conditions. The cultures expressed mRNA constantly after incubation with the extract of CMW 1 cured for 1 h. TGF-β1 specific mRNA was seldom expressed after incubation with the other cement extracts. The release of TGF-β1 into the conditioned medium was increased significantly by CMW 1 extract at 1 h-curing, but was not changed significantly by CMW 1 extract at 7 day-curing and by the extracts of the other cements, at both curing times. The stimulating effect of CMW 1 on the secretion of TGF-β1, even with all the restrictions of an in vitro study of continuous cell lines, if confirmed in vivo, might favor the development of the synovial-like membrane around the implant, and therefore impair the chance of success of the prosthesis." @default.
• W2023896460 created "2016-06-24" @default.
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• W2023896460 date "2002-01-01" @default.
• W2023896460 modified "2023-09-28" @default.
• W2023896460 title "Effect of four acrylic bone cements on transforming growth factor-beta1 expression by osteoblast-like cells MG63" @default.
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• W2023896460 doi "https://doi.org/10.1016/s0142-9612(01)00109-0" @default.
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