FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023902032> ?p ?o ?g. }

• W2023902032 endingPage "461" @default.
• W2023902032 startingPage "453" @default.
• W2023902032 abstract "DOC2 proteins constitute a novel protein family that may function in secretion and contain a double C2 domain. We have cloned and characterized two DOC2 isoforms in rat brain and studied their interactions with other proteins implicated in secretion. DOC2A was virtually brain specific, DOC2B ubiquitous. Within brain, the isoforms were expressed nonuniformly and complementary within neurons, not astroglia, and copurified with synaptic vesicles. Affinity purification, yeast two-hybrid analysis, and coimmunoprecipitation revealed that DOC2 binds munc18, a protein also implicated in secretion. The first DOC2 C2 domain and most of munc18 are involved in direct interactions. Munc18 may regulate formation of `core complexes' during vesicle docking, by interacting with syntaxin. We show that DOC2 and syntaxin compete for munc18. Other core complex components shifted the equilibrium between syntaxin-munc18 versus DOC2-munc18. These data suggest that DOC2 proteins are vesicular adapter proteins regulating munc18-syntaxin complexes and herewith synaptic vesicle docking." @default.
• W2023902032 created "2016-06-24" @default.
• W2023902032 creator A5003932292 @default.
• W2023902032 creator A5020832877 @default.
• W2023902032 creator A5026872836 @default.
• W2023902032 creator A5061921730 @default.
• W2023902032 creator A5085439678 @default.
• W2023902032 creator A5088575640 @default.
• W2023902032 date "1997-03-01" @default.
• W2023902032 modified "2023-10-16" @default.
• W2023902032 title "DOC2 Proteins in Rat Brain: Complementary Distribution and Proposed Function as Vesicular Adapter Proteins in Early Stages of Secretion" @default.
• W2023902032 cites W1949772429 @default.
• W2023902032 cites W1961253883 @default.
• W2023902032 cites W1971016259 @default.
• W2023902032 cites W1977186059 @default.
• W2023902032 cites W1993282564 @default.
• W2023902032 cites W1996223704 @default.
• W2023902032 cites W1998265268 @default.
• W2023902032 cites W2000142886 @default.
• W2023902032 cites W2007984489 @default.
• W2023902032 cites W2008766219 @default.
• W2023902032 cites W2013617213 @default.
• W2023902032 cites W2029160544 @default.
• W2023902032 cites W2044162798 @default.
• W2023902032 cites W2066696278 @default.
• W2023902032 cites W2068446924 @default.
• W2023902032 cites W2078926075 @default.
• W2023902032 cites W2079472796 @default.
• W2023902032 cites W2079750452 @default.
• W2023902032 cites W2081969861 @default.
• W2023902032 cites W2085680244 @default.
• W2023902032 cites W2086036400 @default.
• W2023902032 cites W2087242408 @default.
• W2023902032 cites W2088861631 @default.
• W2023902032 cites W2093467598 @default.
• W2023902032 cites W2094031081 @default.
• W2023902032 cites W2139570277 @default.
• W2023902032 cites W2146785033 @default.
• W2023902032 cites W2165302477 @default.
• W2023902032 cites W321469854 @default.
• W2023902032 cites W4254020147 @default.
• W2023902032 doi "https://doi.org/10.1016/s0896-6273(00)81245-3" @default.
• W2023902032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9115738" @default.
• W2023902032 hasPublicationYear "1997" @default.
• W2023902032 type Work @default.
• W2023902032 sameAs 2023902032 @default.
• W2023902032 citedByCount "159" @default.
• W2023902032 countsByYear W20239020322012 @default.
• W2023902032 countsByYear W20239020322013 @default.
• W2023902032 countsByYear W20239020322014 @default.
• W2023902032 countsByYear W20239020322015 @default.
• W2023902032 countsByYear W20239020322016 @default.
• W2023902032 countsByYear W20239020322017 @default.
• W2023902032 countsByYear W20239020322018 @default.
• W2023902032 countsByYear W20239020322019 @default.
• W2023902032 countsByYear W20239020322020 @default.
• W2023902032 countsByYear W20239020322021 @default.
• W2023902032 countsByYear W20239020322022 @default.
• W2023902032 countsByYear W20239020322023 @default.
• W2023902032 crossrefType "journal-article" @default.
• W2023902032 hasAuthorship W2023902032A5003932292 @default.
• W2023902032 hasAuthorship W2023902032A5020832877 @default.
• W2023902032 hasAuthorship W2023902032A5026872836 @default.
• W2023902032 hasAuthorship W2023902032A5061921730 @default.
• W2023902032 hasAuthorship W2023902032A5085439678 @default.
• W2023902032 hasAuthorship W2023902032A5088575640 @default.
• W2023902032 hasBestOaLocation W20239020321 @default.
• W2023902032 hasConcept C104317684 @default.
• W2023902032 hasConcept C130316041 @default.
• W2023902032 hasConcept C148785051 @default.
• W2023902032 hasConcept C156399914 @default.
• W2023902032 hasConcept C175969161 @default.
• W2023902032 hasConcept C183786373 @default.
• W2023902032 hasConcept C2778256703 @default.
• W2023902032 hasConcept C41625074 @default.
• W2023902032 hasConcept C49039625 @default.
• W2023902032 hasConcept C55493867 @default.
• W2023902032 hasConcept C62478195 @default.
• W2023902032 hasConcept C65972015 @default.
• W2023902032 hasConcept C71829478 @default.
• W2023902032 hasConcept C86803240 @default.
• W2023902032 hasConcept C95444343 @default.
• W2023902032 hasConceptScore W2023902032C104317684 @default.
• W2023902032 hasConceptScore W2023902032C130316041 @default.
• W2023902032 hasConceptScore W2023902032C148785051 @default.
• W2023902032 hasConceptScore W2023902032C156399914 @default.
• W2023902032 hasConceptScore W2023902032C175969161 @default.
• W2023902032 hasConceptScore W2023902032C183786373 @default.
• W2023902032 hasConceptScore W2023902032C2778256703 @default.
• W2023902032 hasConceptScore W2023902032C41625074 @default.
• W2023902032 hasConceptScore W2023902032C49039625 @default.
• W2023902032 hasConceptScore W2023902032C55493867 @default.
• W2023902032 hasConceptScore W2023902032C62478195 @default.
• W2023902032 hasConceptScore W2023902032C65972015 @default.
• W2023902032 hasConceptScore W2023902032C71829478 @default.
• W2023902032 hasConceptScore W2023902032C86803240 @default.
• W2023902032 hasConceptScore W2023902032C95444343 @default.
• W2023902032 hasIssue "3" @default.

• next