FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023902337> ?p ?o ?g. }

• W2023902337 endingPage "571" @default.
• W2023902337 startingPage "551" @default.
• W2023902337 abstract "The context in which amphetamine is administered modulates its ability to induce both behavioral sensitization and immediate early gene expression. When given in a novel test environment amphetamine produces greater levels of c-fos and arc mRNA expression in many brain regions relative to when it is given in the home cage. The purpose of the current study was to determine if environment and drug history interact to influence amphetamine-induced c-fos mRNA expression. Rats with a unilateral 6-hydroxydopamine lesion were treated for 7 days with saline or 0.5 mg/kg of d-amphetamine (i.v.) in a distinct and relatively novel test environment (Novel), or in their home cage (Home). Following a 10-12-day withdrawal period, a challenge injection of either saline or 0.5 mg/kg d-amphetamine was administered. In situ hybridization histochemistry was used to examine c-fos mRNA expression in several regions of the basal ganglia, the central extended amygdala, and limbic forebrain. In most brain regions amphetamine given in the Novel environment produced greater c-fos mRNA expression than when given it was given at Home, and drug history had no effect on amphetamine-induced c-fos mRNA expression. However, within the subthalamic nucleus, substantia nigra reticulata, and central nucleus of the amygdala prior experience with amphetamine in the Novel but not Home environment enhanced the effect of an amphetamine challenge injection on c-fos mRNA expression. In contrast, there was a decrease in c-fos mRNA expression in amphetamine-pretreated animals, regardless of environmental context, in the ventral portion of the far caudal striatum. Reexposure to an environment previously paired with amphetamine produced a conditioned increase in c-fos mRNA expression in portions of the caudate-putamen, the subthalamic nucleus, the nucleus accumbens shell and a conditioned decrease in c-fos mRNA expression in the central nucleus of the amygdala. We conclude that environmental context and drug history interact to alter the basal ganglia and central extended amygdala circuitry engaged by subsequent exposure to amphetamine, or exposure to an environment previously paired with amphetamine." @default.
• W2023902337 created "2016-06-24" @default.
• W2023902337 creator A5002141669 @default.
• W2023902337 creator A5007964297 @default.
• W2023902337 creator A5008618384 @default.
• W2023902337 creator A5029245318 @default.
• W2023902337 creator A5049286080 @default.
• W2023902337 creator A5071391619 @default.
• W2023902337 creator A5076863032 @default.
• W2023902337 date "2003-08-01" @default.
• W2023902337 modified "2023-10-18" @default.
• W2023902337 title "Environmental context and drug history modulate amphetamine-induced c-fos mrna expression in the basal ganglia, central extended amygdala, and associated limbic forebrain" @default.
• W2023902337 cites W1018780083 @default.
• W2023902337 cites W1522286249 @default.
• W2023902337 cites W1523637894 @default.
• W2023902337 cites W1541410122 @default.
• W2023902337 cites W1585501195 @default.
• W2023902337 cites W1605427252 @default.
• W2023902337 cites W16397587 @default.
• W2023902337 cites W1680771593 @default.
• W2023902337 cites W1708252865 @default.
• W2023902337 cites W1714742035 @default.
• W2023902337 cites W1828572233 @default.
• W2023902337 cites W1966533004 @default.
• W2023902337 cites W1967186470 @default.
• W2023902337 cites W1967784117 @default.
• W2023902337 cites W1968307109 @default.
• W2023902337 cites W1970764579 @default.
• W2023902337 cites W1975280088 @default.
• W2023902337 cites W1976117761 @default.
• W2023902337 cites W1980018349 @default.
• W2023902337 cites W1980191955 @default.
• W2023902337 cites W1981737615 @default.
• W2023902337 cites W1982072195 @default.
• W2023902337 cites W1984620843 @default.
• W2023902337 cites W1987243354 @default.
• W2023902337 cites W1988048218 @default.
• W2023902337 cites W1988238952 @default.
• W2023902337 cites W1990377586 @default.
• W2023902337 cites W1991127151 @default.
• W2023902337 cites W1996704538 @default.
• W2023902337 cites W1996809124 @default.
• W2023902337 cites W2001710735 @default.
• W2023902337 cites W2003289804 @default.
• W2023902337 cites W2004931312 @default.
• W2023902337 cites W2008106418 @default.
• W2023902337 cites W2008526948 @default.
• W2023902337 cites W2008563188 @default.
• W2023902337 cites W2010156528 @default.
• W2023902337 cites W2012197992 @default.
• W2023902337 cites W2012203368 @default.
• W2023902337 cites W2015081846 @default.
• W2023902337 cites W2016103580 @default.
• W2023902337 cites W2016866955 @default.
• W2023902337 cites W2017277436 @default.
• W2023902337 cites W2018040121 @default.
• W2023902337 cites W2019580148 @default.
• W2023902337 cites W2019790635 @default.
• W2023902337 cites W2021889209 @default.
• W2023902337 cites W2024398740 @default.
• W2023902337 cites W2027507975 @default.
• W2023902337 cites W2027857210 @default.
• W2023902337 cites W2030130447 @default.
• W2023902337 cites W2041993019 @default.
• W2023902337 cites W2043041186 @default.
• W2023902337 cites W2047919057 @default.
• W2023902337 cites W2050279789 @default.
• W2023902337 cites W2050295909 @default.
• W2023902337 cites W2053873291 @default.
• W2023902337 cites W2059568782 @default.
• W2023902337 cites W2059582144 @default.
• W2023902337 cites W2060588252 @default.
• W2023902337 cites W2063055166 @default.
• W2023902337 cites W2063539865 @default.
• W2023902337 cites W2064999014 @default.
• W2023902337 cites W2067952794 @default.
• W2023902337 cites W2069409350 @default.
• W2023902337 cites W2069550549 @default.
• W2023902337 cites W2070403533 @default.
• W2023902337 cites W2072157553 @default.
• W2023902337 cites W2072971712 @default.
• W2023902337 cites W2074061123 @default.
• W2023902337 cites W2076635082 @default.
• W2023902337 cites W2080288627 @default.
• W2023902337 cites W2085867048 @default.
• W2023902337 cites W2089654556 @default.
• W2023902337 cites W2091497325 @default.
• W2023902337 cites W2091553801 @default.
• W2023902337 cites W2093890578 @default.
• W2023902337 cites W2094075491 @default.
• W2023902337 cites W2095395905 @default.
• W2023902337 cites W2097486305 @default.
• W2023902337 cites W2100580768 @default.
• W2023902337 cites W2101658107 @default.
• W2023902337 cites W2103018978 @default.
• W2023902337 cites W2106862702 @default.
• W2023902337 cites W2109723563 @default.
• W2023902337 cites W2111885726 @default.

• next