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• W2023906623 endingPage "694" @default.
• W2023906623 startingPage "685" @default.
• W2023906623 abstract "The questions of T cell receptor (TCR) clustering and preferential pairing of TCR alpha- and beta-chains are discussed controversially. We here describe the rare case of a non-pairing TCR alpha-TCR beta combination detected in the murine T cell hybridoma Hy-E6. Of its two TCR alpha-chains (Valpha3.2, Vbeta17) and one Vbeta16-chain only the Valpha17/Vbeta16 TCR is exposed on the surface, despite intracellular expression of Valpha3.2 protein. The lack of Valpha3.2/Vbeta16 pairing was confirmed by TCR transfections. Surprisingly, however, the parental T cell clone CTL-E6 expressed both alpha-chains on its plasma membrane. Different size distribution of TCR clusters in CTL-E6 versus Hy-E6 and transfectants as determined by Blue-Native gel electrophoresis indicated differences in the supra-molecular TCR assembly as one possible reason for this phenomenon. Our data further reveal that the nominal specificity of CTL-E6 for the fully agonistic trinitrophenyl (TNP) modified peptide M4L-TNP was specifically mediated by the trimeric Valpha3.2/Valpha17/Vbeta16 TCR of CTL-E6. In contrast, the Valpha17/Vbeta16 combination in Hy-E6 only conferred specificity for the cross-reactive partial agonist O4-TNP. Both specificities are H-2Kb-restricted and, hence, appear to be positively selected. The differences in TCR clustering in CTL and hybridoma might indicate differences in the reception and transmission of TCR-signals between these two cell types." @default.
• W2023906623 created "2016-06-24" @default.
• W2023906623 creator A5004875529 @default.
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• W2023906623 creator A5014552408 @default.
• W2023906623 creator A5033597781 @default.
• W2023906623 creator A5091505731 @default.
• W2023906623 date "2005-11-01" @default.
• W2023906623 modified "2023-09-25" @default.
• W2023906623 title "Differences in pairing and cluster formation of T cell receptor α- and β-chains in T cell clones and fusion hybridomas" @default.
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• W2023906623 doi "https://doi.org/10.1016/j.imbio.2005.07.002" @default.
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