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- W2023908037 abstract "The serum protein binding of racemic warfarin was determined in 209 adult male Sprague-Dawley rats. Statistical analysis of a histogram of warfarin free fraction values (ratio of concentrations of free and free plus bound drug) revealed modes at free fraction values of 0.0040, 0.0112, and 0.0166, with more than one-half of the animals included in the Gaussian component with the lowest free fraction mode. Since the total clearance of warfarin is proportional to the free fraction value and since the intrinsic clearance of warfarin in these rats is relatively constant, the trimodal distribution of free fraction values reflects a corresponding distribution of warfarin clearance values." @default.
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- W2023908037 date "1976-08-01" @default.
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- W2023908037 title "Multimodal distribution of warfarin binding to protein in serum of male-sprague dawley rats" @default.
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- W2023908037 doi "https://doi.org/10.1016/0024-3205(76)90053-9" @default.
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