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• W2023908280 abstract "SUMMARY The immune responses of schoolchildren in southeast England to Mycobacterium tuberculosis and other species of mycobacteria were studied prior to vaccination with bacille Calmette-Guérin (BCG). Data are presented for tuberculin (Heaf) skin test and interferon-γ (IFN-γ) responses to M. tuberculosis purified protein derivative (PPD), and IFN-γ responses to PPDs from eight other environmental mycobacteria, measured in 424 schoolchildren (13–15 years of age). Responses to M. tuberculosis PPD were detected in 27% of schoolchildren by in vitro IFN-γ response and in 20% by the Heaf test. IFN-γ responses were more prevalent to PPDs from species of mycobacteria other than M. tuberculosis, predominantly those of the MAIS complex and M. marinum (45–60% responders). Heaf test and IFN-γ responses were associated (P &lt; 0·001) for M. tuberculosis, MAIS and M. marinum. These findings have implications for appropriate implementation of vaccination against tuberculosis." @default.
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• W2023908280 date "2003-09-26" @default.
• W2023908280 modified "2023-09-23" @default.
• W2023908280 title "Interferon-γ and skin test responses of schoolchildren in southeast England to purified protein derivatives from <i>Mycobacterium tuberculosis</i> and other species of mycobacteria" @default.
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• W2023908280 doi "https://doi.org/10.1046/j.1365-2249.2003.02272" @default.
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