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• W2023909595 startingPage "1036" @default.
• W2023909595 abstract "This review summarizes and comments on the current understanding of both the biochemical and clinical implications of the epimerization of R-aryl propionic (APA) class (1) nonsteroidal anti-inflammatory agents (NSAIDs) to S-enantiomers in humans. This article focuses principally on rac-ibuprofen and its enantiomers. In the United States, five commercialized NSAIDs are APAs. Only two of them, rac-ibuprofen and rac-fenoprofen, are subject to significant epimerization in humans. The remaining three, rac-flurbiprofen, rac-ketoprofen, and S-naproxen, are not of interest in this context." @default.
• W2023909595 created "2016-06-24" @default.
• W2023909595 creator A5041935628 @default.
• W2023909595 date "1994-11-01" @default.
• W2023909595 modified "2023-10-17" @default.
• W2023909595 title "Drug Chirality: On the Mechanism of R‐Aryl Propionic Acid Class NSAIDs. Epimerization in Humans and the Clinical Implications for the Use of Racemates" @default.
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• W2023909595 doi "https://doi.org/10.1002/j.1552-4604.1994.tb01977.x" @default.
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