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- W2023921283 endingPage "17572" @default.
- W2023921283 startingPage "17553" @default.
- W2023921283 abstract "Dopamine, which is synthesized in the kidney, independent of renal nerves, plays an important role in the regulation of fluid and electrolyte balance and systemic blood pressure. Lack of any of the five dopamine receptor subtypes (D1R, D2R, D3R, D4R, and D5R) results in hypertension. D1R, D2R, and D5R have been reported to be important in the maintenance of a normal redox balance. In the kidney, the antioxidant effects of these receptors are caused by direct and indirect inhibition of pro-oxidant enzymes, specifically, nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase, and stimulation of anti-oxidant enzymes, which can also indirectly inhibit NADPH oxidase activity. Thus, stimulation of the D2R increases the expression of endogenous anti-oxidants, such as Parkinson protein 7 (PARK7 or DJ-1), paraoxonase 2 (PON2), and heme oxygenase 2 (HO-2), all of which can inhibit NADPH oxidase activity. The D5R decreases NADPH oxidase activity, via the inhibition of phospholipase D2, and increases the expression of HO-1, another antioxidant. D1R inhibits NADPH oxidase activity via protein kinase A and protein kinase C cross-talk. In this review, we provide an overview of the protective roles of a specific dopamine receptor subtype on renal oxidative stress, the different mechanisms involved in this effect, and the role of oxidative stress and impairment of dopamine receptor function in the hypertension that arises from the genetic ablation of a specific dopamine receptor gene in mice." @default.
- W2023921283 created "2016-06-24" @default.
- W2023921283 creator A5063454640 @default.
- W2023921283 creator A5075088009 @default.
- W2023921283 creator A5089297328 @default.
- W2023921283 creator A5089449841 @default.
- W2023921283 date "2013-08-27" @default.
- W2023921283 modified "2023-10-01" @default.
- W2023921283 title "Renal Dopamine Receptors, Oxidative Stress, and Hypertension" @default.
- W2023921283 cites W1540141415 @default.
- W2023921283 cites W1553261973 @default.
- W2023921283 cites W1590514634 @default.
- W2023921283 cites W1725973209 @default.
- W2023921283 cites W1797331685 @default.
- W2023921283 cites W1921965616 @default.
- W2023921283 cites W1967380701 @default.
- W2023921283 cites W1968914101 @default.
- W2023921283 cites W1972010974 @default.
- W2023921283 cites W1973241225 @default.
- W2023921283 cites W1973474734 @default.
- W2023921283 cites W1974834837 @default.
- W2023921283 cites W1975932722 @default.
- W2023921283 cites W1976357583 @default.
- W2023921283 cites W1977990240 @default.
- W2023921283 cites W1978416333 @default.
- W2023921283 cites W1979416592 @default.
- W2023921283 cites W1980504496 @default.
- W2023921283 cites W1985091168 @default.
- W2023921283 cites W1985399632 @default.
- W2023921283 cites W1989072182 @default.
- W2023921283 cites W1989425675 @default.
- W2023921283 cites W1993336124 @default.
- W2023921283 cites W1993961540 @default.
- W2023921283 cites W1993964967 @default.
- W2023921283 cites W1995412458 @default.
- W2023921283 cites W1995629156 @default.
- W2023921283 cites W2002820793 @default.
- W2023921283 cites W2003847258 @default.
- W2023921283 cites W2004129180 @default.
- W2023921283 cites W2004763365 @default.
- W2023921283 cites W2007074501 @default.
- W2023921283 cites W2007317026 @default.
- W2023921283 cites W2010502534 @default.
- W2023921283 cites W2011595187 @default.
- W2023921283 cites W2015194256 @default.
- W2023921283 cites W2018764046 @default.
- W2023921283 cites W2019962808 @default.
- W2023921283 cites W2022671309 @default.
- W2023921283 cites W2026433745 @default.
- W2023921283 cites W2026749538 @default.
- W2023921283 cites W2026841498 @default.
- W2023921283 cites W2031677574 @default.
- W2023921283 cites W2032236480 @default.
- W2023921283 cites W2033988038 @default.
- W2023921283 cites W2034754688 @default.
- W2023921283 cites W2034853255 @default.
- W2023921283 cites W2037775441 @default.
- W2023921283 cites W2042805424 @default.
- W2023921283 cites W2044395254 @default.
- W2023921283 cites W2046465340 @default.
- W2023921283 cites W2046687158 @default.
- W2023921283 cites W2046741486 @default.
- W2023921283 cites W2047886591 @default.
- W2023921283 cites W2050280508 @default.
- W2023921283 cites W2053229908 @default.
- W2023921283 cites W2054877510 @default.
- W2023921283 cites W2059467226 @default.
- W2023921283 cites W2064929307 @default.
- W2023921283 cites W2065080605 @default.
- W2023921283 cites W2065295009 @default.
- W2023921283 cites W2067416965 @default.
- W2023921283 cites W2068544753 @default.
- W2023921283 cites W2070766926 @default.
- W2023921283 cites W2070880233 @default.
- W2023921283 cites W2071362963 @default.
- W2023921283 cites W2074210072 @default.
- W2023921283 cites W2074397899 @default.
- W2023921283 cites W2075439203 @default.
- W2023921283 cites W2075541529 @default.
- W2023921283 cites W2076424973 @default.
- W2023921283 cites W2076546188 @default.
- W2023921283 cites W2077821351 @default.
- W2023921283 cites W2077924160 @default.
- W2023921283 cites W2078693672 @default.
- W2023921283 cites W2087788920 @default.
- W2023921283 cites W2097086721 @default.
- W2023921283 cites W2098470881 @default.
- W2023921283 cites W2099040294 @default.
- W2023921283 cites W2101940897 @default.
- W2023921283 cites W2102485320 @default.
- W2023921283 cites W2102990177 @default.
- W2023921283 cites W2103757082 @default.
- W2023921283 cites W2103929027 @default.
- W2023921283 cites W2113352370 @default.
- W2023921283 cites W2114239078 @default.
- W2023921283 cites W2114705064 @default.
- W2023921283 cites W2115933163 @default.
- W2023921283 cites W2116109401 @default.