Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023922017> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2023922017 endingPage "1059" @default.
- W2023922017 startingPage "1054" @default.
- W2023922017 abstract "Although the sympathomimetic actions and cardiovascular complications of cocaine are ascribed to inhibition of norepinephrine (NE) reuptake, this hypothesis has not been tested in humans. We asked (a) whether cocaine can inhibit NE reuptake in the human peripheral circulation and (b) whether the NE-mediated peripheral vasoconstriction is the main mechanism mediating blood pressure-raising effect of cocaine.In 15 healthy cocaine-naive subjects, we measured blood pressure, forearm blood flow, and forearm venous NE concentration during administration of (a) intrabrachial cocaine (0.15 and 15 mg), which produced no systemic neurohormonal effects, and (b) intranasal cocaine (2 mg/kg). Intrabrachial cocaine (0.15 mg) increased venous forearm NE concentration by 82% and vascular resistance by 71% (P<0.01). Increasing the intrabrachial cocaine dose by 100-fold to match the venous cocaine level of massive cocaine overdose caused a small additional increase in venous forearm NE concentration without causing significant additional vasoconstriction. Although intranasal cocaine (2 mg/kg) matched the venous cocaine concentrations caused by 0.15 mg of intrabrachial cocaine, venous NE concentration was unchanged as sympathetic nerve activity (SNA) decreased reflexively as the result of an increase in blood pressure. When SNA was restored to baseline by blunting the cocaine-induced rise in blood pressure (baroreflex activation) with nitroprusside, venous NE concentration increased to the same level caused by intrabrachial cocaine.In healthy cocaine-naive individuals, cocaine can inhibit NE reuptake in the human peripheral circulation. However, this mechanism does not contribute importantly to the blood pressure-raising effect of cocaine because activation of baroreceptor reflexes decreases SNA, the neural stimulus for NE release." @default.
- W2023922017 created "2016-06-24" @default.
- W2023922017 creator A5011058208 @default.
- W2023922017 creator A5036562947 @default.
- W2023922017 creator A5038470631 @default.
- W2023922017 creator A5062302009 @default.
- W2023922017 creator A5075501249 @default.
- W2023922017 creator A5084255283 @default.
- W2023922017 date "2002-03-05" @default.
- W2023922017 modified "2023-09-23" @default.
- W2023922017 title "Mechanism of the Blood Pressure—Raising Effect of Cocaine in Humans" @default.
- W2023922017 cites W1896419431 @default.
- W2023922017 cites W1979797353 @default.
- W2023922017 cites W1986502594 @default.
- W2023922017 cites W1989328304 @default.
- W2023922017 cites W1999413134 @default.
- W2023922017 cites W2030668773 @default.
- W2023922017 cites W2038722620 @default.
- W2023922017 cites W2043440982 @default.
- W2023922017 cites W2057996376 @default.
- W2023922017 cites W207011981 @default.
- W2023922017 cites W2073152491 @default.
- W2023922017 cites W2086378859 @default.
- W2023922017 cites W2316853010 @default.
- W2023922017 cites W2338565293 @default.
- W2023922017 cites W2614758074 @default.
- W2023922017 doi "https://doi.org/10.1161/hc0902.104714" @default.
- W2023922017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11877354" @default.
- W2023922017 hasPublicationYear "2002" @default.
- W2023922017 type Work @default.
- W2023922017 sameAs 2023922017 @default.
- W2023922017 citedByCount "39" @default.
- W2023922017 countsByYear W20239220172012 @default.
- W2023922017 countsByYear W20239220172013 @default.
- W2023922017 countsByYear W20239220172014 @default.
- W2023922017 countsByYear W20239220172016 @default.
- W2023922017 countsByYear W20239220172017 @default.
- W2023922017 countsByYear W20239220172019 @default.
- W2023922017 countsByYear W20239220172021 @default.
- W2023922017 crossrefType "journal-article" @default.
- W2023922017 hasAuthorship W2023922017A5011058208 @default.
- W2023922017 hasAuthorship W2023922017A5036562947 @default.
- W2023922017 hasAuthorship W2023922017A5038470631 @default.
- W2023922017 hasAuthorship W2023922017A5062302009 @default.
- W2023922017 hasAuthorship W2023922017A5075501249 @default.
- W2023922017 hasAuthorship W2023922017A5084255283 @default.
- W2023922017 hasBestOaLocation W20239220171 @default.
- W2023922017 hasConcept C126322002 @default.
- W2023922017 hasConcept C141071460 @default.
- W2023922017 hasConcept C178853913 @default.
- W2023922017 hasConcept C2778514916 @default.
- W2023922017 hasConcept C2779961880 @default.
- W2023922017 hasConcept C2780214079 @default.
- W2023922017 hasConcept C42219234 @default.
- W2023922017 hasConcept C43044207 @default.
- W2023922017 hasConcept C47323905 @default.
- W2023922017 hasConcept C513476851 @default.
- W2023922017 hasConcept C58245268 @default.
- W2023922017 hasConcept C71924100 @default.
- W2023922017 hasConcept C84393581 @default.
- W2023922017 hasConceptScore W2023922017C126322002 @default.
- W2023922017 hasConceptScore W2023922017C141071460 @default.
- W2023922017 hasConceptScore W2023922017C178853913 @default.
- W2023922017 hasConceptScore W2023922017C2778514916 @default.
- W2023922017 hasConceptScore W2023922017C2779961880 @default.
- W2023922017 hasConceptScore W2023922017C2780214079 @default.
- W2023922017 hasConceptScore W2023922017C42219234 @default.
- W2023922017 hasConceptScore W2023922017C43044207 @default.
- W2023922017 hasConceptScore W2023922017C47323905 @default.
- W2023922017 hasConceptScore W2023922017C513476851 @default.
- W2023922017 hasConceptScore W2023922017C58245268 @default.
- W2023922017 hasConceptScore W2023922017C71924100 @default.
- W2023922017 hasConceptScore W2023922017C84393581 @default.
- W2023922017 hasIssue "9" @default.
- W2023922017 hasLocation W20239220171 @default.
- W2023922017 hasLocation W20239220172 @default.
- W2023922017 hasOpenAccess W2023922017 @default.
- W2023922017 hasPrimaryLocation W20239220171 @default.
- W2023922017 hasRelatedWork W2048852309 @default.
- W2023922017 hasRelatedWork W2067994986 @default.
- W2023922017 hasRelatedWork W2079903996 @default.
- W2023922017 hasRelatedWork W2105480884 @default.
- W2023922017 hasRelatedWork W2298178871 @default.
- W2023922017 hasRelatedWork W2400149166 @default.
- W2023922017 hasRelatedWork W2419030302 @default.
- W2023922017 hasRelatedWork W2419661314 @default.
- W2023922017 hasRelatedWork W2461164304 @default.
- W2023922017 hasRelatedWork W4290303815 @default.
- W2023922017 hasVolume "105" @default.
- W2023922017 isParatext "false" @default.
- W2023922017 isRetracted "false" @default.
- W2023922017 magId "2023922017" @default.
- W2023922017 workType "article" @default.