Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023923955> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2023923955 endingPage "1162" @default.
- W2023923955 startingPage "1159" @default.
- W2023923955 abstract "Cytochrome P4501A1 (CYP1A1) and the UDP-glucuronosyltransferase isoform UGT1A6 were studied in pharyngeal mucosa and squamous cancer tissue obtained from 27 male subjects (10 healthy nonsmoking volunteers, 10 smokers, and 7 smokers with pharyngeal cancer). CYP1A activity (7-ethoxyresorufin O-deethylase) was significantly induced in smokers as compared to nonsmokers (2.3 +/- 1.1 and 0.8 +/- 0.4 pmol x min[-1] x mg protein[-1], respectively). Immunoblot analysis demonstrated enhanced CYP1A1 protein in smokers. UGT activity towards 4-methylumbelliferone and 1-naphthol was also detectable in oropharyngeal mucosa. RT-PCR (reverse transcriptase-polymerase chain reaction) analysis indicated that UGT activity was at least in part due to the expression of UGT1A6. In cancer tissue, CYP1A activity was decreased in comparison with surrounding healthy mucosa (1.2 +/- 0.9 in tumor tissue vs. 2.2 +/- 0.7 pmol x min[-1] x mg protein[-1], respectively), whereas means and medians of UGT activity were unchanged. The results suggest that phase I and II drug-metabolizing enzymes are detectable in oropharyngeal mucosa and that CYP1A activity is inducible by constituents of cigarette smoke." @default.
- W2023923955 created "2016-06-24" @default.
- W2023923955 creator A5004867526 @default.
- W2023923955 creator A5012155889 @default.
- W2023923955 creator A5032074919 @default.
- W2023923955 creator A5066014226 @default.
- W2023923955 creator A5073096233 @default.
- W2023923955 date "1997-11-01" @default.
- W2023923955 modified "2023-10-18" @default.
- W2023923955 title "Drug-Metabolizing Enzymes in Pharyngeal Mucosa and in Oropharyngeal Cancer Tissue" @default.
- W2023923955 cites W1508115080 @default.
- W2023923955 cites W1572023751 @default.
- W2023923955 cites W1775749144 @default.
- W2023923955 cites W1970850435 @default.
- W2023923955 cites W1977951934 @default.
- W2023923955 cites W2063839576 @default.
- W2023923955 cites W2065502205 @default.
- W2023923955 cites W2072004105 @default.
- W2023923955 cites W2127424871 @default.
- W2023923955 cites W2132927623 @default.
- W2023923955 cites W2167066375 @default.
- W2023923955 cites W2170831027 @default.
- W2023923955 cites W4292230194 @default.
- W2023923955 cites W4294216491 @default.
- W2023923955 doi "https://doi.org/10.1016/s0006-2952(97)00347-x" @default.
- W2023923955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9464459" @default.
- W2023923955 hasPublicationYear "1997" @default.
- W2023923955 type Work @default.
- W2023923955 sameAs 2023923955 @default.
- W2023923955 citedByCount "11" @default.
- W2023923955 countsByYear W20239239552012 @default.
- W2023923955 countsByYear W20239239552020 @default.
- W2023923955 countsByYear W20239239552021 @default.
- W2023923955 crossrefType "journal-article" @default.
- W2023923955 hasAuthorship W2023923955A5004867526 @default.
- W2023923955 hasAuthorship W2023923955A5012155889 @default.
- W2023923955 hasAuthorship W2023923955A5032074919 @default.
- W2023923955 hasAuthorship W2023923955A5066014226 @default.
- W2023923955 hasAuthorship W2023923955A5073096233 @default.
- W2023923955 hasConcept C114246631 @default.
- W2023923955 hasConcept C121608353 @default.
- W2023923955 hasConcept C126322002 @default.
- W2023923955 hasConcept C134018914 @default.
- W2023923955 hasConcept C153911025 @default.
- W2023923955 hasConcept C181199279 @default.
- W2023923955 hasConcept C185592680 @default.
- W2023923955 hasConcept C2780035454 @default.
- W2023923955 hasConcept C526171541 @default.
- W2023923955 hasConcept C55493867 @default.
- W2023923955 hasConcept C71924100 @default.
- W2023923955 hasConcept C86803240 @default.
- W2023923955 hasConcept C89311334 @default.
- W2023923955 hasConcept C98274493 @default.
- W2023923955 hasConceptScore W2023923955C114246631 @default.
- W2023923955 hasConceptScore W2023923955C121608353 @default.
- W2023923955 hasConceptScore W2023923955C126322002 @default.
- W2023923955 hasConceptScore W2023923955C134018914 @default.
- W2023923955 hasConceptScore W2023923955C153911025 @default.
- W2023923955 hasConceptScore W2023923955C181199279 @default.
- W2023923955 hasConceptScore W2023923955C185592680 @default.
- W2023923955 hasConceptScore W2023923955C2780035454 @default.
- W2023923955 hasConceptScore W2023923955C526171541 @default.
- W2023923955 hasConceptScore W2023923955C55493867 @default.
- W2023923955 hasConceptScore W2023923955C71924100 @default.
- W2023923955 hasConceptScore W2023923955C86803240 @default.
- W2023923955 hasConceptScore W2023923955C89311334 @default.
- W2023923955 hasConceptScore W2023923955C98274493 @default.
- W2023923955 hasIssue "10" @default.
- W2023923955 hasLocation W20239239551 @default.
- W2023923955 hasLocation W20239239552 @default.
- W2023923955 hasOpenAccess W2023923955 @default.
- W2023923955 hasPrimaryLocation W20239239551 @default.
- W2023923955 hasRelatedWork W1986974279 @default.
- W2023923955 hasRelatedWork W1993084845 @default.
- W2023923955 hasRelatedWork W2028506307 @default.
- W2023923955 hasRelatedWork W2032702940 @default.
- W2023923955 hasRelatedWork W2126349937 @default.
- W2023923955 hasRelatedWork W2132714283 @default.
- W2023923955 hasRelatedWork W2225739041 @default.
- W2023923955 hasRelatedWork W2291003988 @default.
- W2023923955 hasRelatedWork W2339044507 @default.
- W2023923955 hasRelatedWork W83734833 @default.
- W2023923955 hasVolume "54" @default.
- W2023923955 isParatext "false" @default.
- W2023923955 isRetracted "false" @default.
- W2023923955 magId "2023923955" @default.
- W2023923955 workType "article" @default.