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- W2023930459 abstract "The effects of resuscitation of traumatic—hemorrhagic shock on the brain are unknown. Traumatic shock in sheep (fracture/crush injury, 2-hr hemorrhage to 40 mm Hg) was followed by resuscitation to baseline mean arterial pressure. Two groups without brain injury were resuscitated with lactated Ringer's (LR1, n = 7) or albumin (ALB1, n = 6). Focal brain injury was added in two further groups (LR2, n = 6; ALB2, n = 6). Hemodynamics, intracranial pressure (ICP), EEG, and colloid osmotic pressure (COP) were followed. Brain water (BW) and cerebral blood volume (CBV) were compared to those of controls (C, n = 7). Results: ICP rose in all groups. Animals without brain injury did not have increased brain water. Below are results for brain-injured animals after resuscitation (mean ± SEM). ∗ Parameter Baseline Lactated Ringer's Albumin Resuscitation volume (ml/kg) 107.8 ± 14.5 44.4 ± 4.0 ∗ P < 0.05, LR vs ALB. COP (mm Hg) 20.8 ± 1.1 12.0 ± 0.8 21.8 ± 0.8 ∗ P < 0.05, LR vs ALB. ICP (mm Hg) 12.5 ± 1.4 19.0 ± 1.4 15.2 ± 2.3 Mean EEG (Hz) 3.9 ± 1.2 8.1 ± 1.5 7.4 ± 1.0 BW (%) 80.4 ± 0.7 (control) 86.0 ± 0.4 P < 0.05 vs control. 86.0 ± 0.9 P < 0.05 vs control. CBV (%) 3.1 ± 0.6 (control) 1.7 ± 0.2 3.2 ± 1.3 ∗ , LR vs ALB. ∗∗ vs control. Open table in a new tab Maintaining COP during initial resuscitation does not minimize cerebral edema: the effects of LR and ALB were similar in this setting. Focal brain injury causes edema but does not cause large increases in ICP with initial resuscitation." @default.
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- W2023930459 date "1989-01-01" @default.
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- W2023930459 title "Traumatic shock and head injury: Effects of fluid resuscitation on the brain" @default.
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- W2023930459 doi "https://doi.org/10.1016/0022-4804(89)90181-9" @default.
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