FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023931269> ?p ?o ?g. }

• W2023931269 endingPage "199" @default.
• W2023931269 startingPage "184" @default.
• W2023931269 abstract "Nerve-evoked contractile activity in skeletal muscle regulates transcript and protein levels of many metabolic genes in a coordinate fashion, including the muscle isozyme of glycogen phosphorylase (MGP). Cellular signaling mechanisms mediating the activity-dependent modulation of MGP transcript levels were investigated in a spontaneously contractile rat skeletal muscle cell line (Rmo). Mechanisms regulating MGP mRNA levels in Rmo myotubes were compared with those previously shown to modulate the gene encoding the alpha subunit of the acetylcholine receptor (alphaAChR). Reducing the resting membrane potential from -78 to -30 mV, either electrochemically (KCl) or by increasing Na(+) permeability (veratridine): (1) prevented activation of transverse tubules, (2) impeded calcium release by the sarcoplasmic reticulum (SR), and (3) blocked Rmo contractility. MGP mRNA levels decreased to 30% of control levels and alphaAChR levels increased to 350% following 24 h of depolarization. Differing mechanisms appear to mediate this voltage-dependent regulation of MGP and alphaAChR. Inhibition of SR calcium efflux selectively decreased MGP mRNA levels by 30-50% when using dantrolene, thapsigargin, or a dose of ryanodine shown to inactivate Ca(2+)-induced SR Ca(2+) release (CICR). By contrast, blockade of voltage sensors in transverse tubules with nifedipine, a dihydroaminopyridine (DHAP) antagonist, selectively increased alphaAChR mRNA levels by twofold. These data indicate that the voltage-dependent regulation of AChR gene expression differs from that modulating the MGP gene. KCl-induced depolarization and dantrolene both inhibit pulsatile SR Ca(2+) efflux in Rmo myotubes, but by differing mechanisms. Depolarization and dantrolene comparably reduced MGP mRNA levels and decreased MGP transcript stability from a t(1/2) of 24 h to 14.5 and 16 h, respectively. Reduced transcript stability can account for the observed reduction in mRNA levels of MGP in noncontractile Rmo myotubes and could be a significant regulatory mechanism in skeletal muscle that coordinates the activity-dependent expression of MGP with other glycogenolytic genes." @default.
• W2023931269 created "2016-06-24" @default.
• W2023931269 creator A5052564856 @default.
• W2023931269 creator A5056961084 @default.
• W2023931269 creator A5062413385 @default.
• W2023931269 creator A5082167328 @default.
• W2023931269 date "2000-01-01" @default.
• W2023931269 modified "2023-09-25" @default.
• W2023931269 title "Role of the sarcoplasmic reticulum in regulating the activity-dependent expression of the glycogen phosphorylase gene in contractile skeletal muscle cells" @default.
• W2023931269 cites W120737279 @default.
• W2023931269 cites W1503010601 @default.
• W2023931269 cites W1516049011 @default.
• W2023931269 cites W1527237994 @default.
• W2023931269 cites W1534636938 @default.
• W2023931269 cites W1546293850 @default.
• W2023931269 cites W1568102351 @default.
• W2023931269 cites W1595570385 @default.
• W2023931269 cites W1650401181 @default.
• W2023931269 cites W1666469474 @default.
• W2023931269 cites W1825217901 @default.
• W2023931269 cites W1972939655 @default.
• W2023931269 cites W1975700762 @default.
• W2023931269 cites W1992236027 @default.
• W2023931269 cites W1994109113 @default.
• W2023931269 cites W2008705738 @default.
• W2023931269 cites W2011615820 @default.
• W2023931269 cites W2026640337 @default.
• W2023931269 cites W2038207545 @default.
• W2023931269 cites W2040268666 @default.
• W2023931269 cites W2045751356 @default.
• W2023931269 cites W2046801181 @default.
• W2023931269 cites W2051240076 @default.
• W2023931269 cites W2056208343 @default.
• W2023931269 cites W2063987923 @default.
• W2023931269 cites W2065267195 @default.
• W2023931269 cites W2067502143 @default.
• W2023931269 cites W2076899915 @default.
• W2023931269 cites W2078652054 @default.
• W2023931269 cites W2078811540 @default.
• W2023931269 cites W2078923351 @default.
• W2023931269 cites W2079756784 @default.
• W2023931269 cites W2081570207 @default.
• W2023931269 cites W2081943401 @default.
• W2023931269 cites W2084939728 @default.
• W2023931269 cites W2086178730 @default.
• W2023931269 cites W2089744349 @default.
• W2023931269 cites W2141260882 @default.
• W2023931269 cites W2188442396 @default.
• W2023931269 cites W2305041573 @default.
• W2023931269 cites W2346502573 @default.
• W2023931269 cites W2346624471 @default.
• W2023931269 cites W2428156249 @default.
• W2023931269 cites W4243685857 @default.
• W2023931269 cites W4298222710 @default.
• W2023931269 cites W86465798 @default.
• W2023931269 doi "https://doi.org/10.1002/1097-4652(200011)185:2<184::aid-jcp3>3.0.co;2-t" @default.
• W2023931269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11025440" @default.
• W2023931269 hasPublicationYear "2000" @default.
• W2023931269 type Work @default.
• W2023931269 sameAs 2023931269 @default.
• W2023931269 citedByCount "14" @default.
• W2023931269 countsByYear W20239312692012 @default.
• W2023931269 countsByYear W20239312692013 @default.
• W2023931269 countsByYear W20239312692015 @default.
• W2023931269 countsByYear W20239312692016 @default.
• W2023931269 countsByYear W20239312692018 @default.
• W2023931269 crossrefType "journal-article" @default.
• W2023931269 hasAuthorship W2023931269A5052564856 @default.
• W2023931269 hasAuthorship W2023931269A5056961084 @default.
• W2023931269 hasAuthorship W2023931269A5062413385 @default.
• W2023931269 hasAuthorship W2023931269A5082167328 @default.
• W2023931269 hasConcept C113217602 @default.
• W2023931269 hasConcept C126322002 @default.
• W2023931269 hasConcept C134018914 @default.
• W2023931269 hasConcept C158617107 @default.
• W2023931269 hasConcept C178790620 @default.
• W2023931269 hasConcept C181199279 @default.
• W2023931269 hasConcept C185592680 @default.
• W2023931269 hasConcept C207200792 @default.
• W2023931269 hasConcept C23265538 @default.
• W2023931269 hasConcept C2776986425 @default.
• W2023931269 hasConcept C2777146706 @default.
• W2023931269 hasConcept C2779959927 @default.
• W2023931269 hasConcept C2781414619 @default.
• W2023931269 hasConcept C2781460320 @default.
• W2023931269 hasConcept C3763915 @default.
• W2023931269 hasConcept C4141045 @default.
• W2023931269 hasConcept C50952357 @default.
• W2023931269 hasConcept C519063684 @default.
• W2023931269 hasConcept C537181965 @default.
• W2023931269 hasConcept C55493867 @default.
• W2023931269 hasConcept C71924100 @default.
• W2023931269 hasConcept C86803240 @default.
• W2023931269 hasConcept C95444343 @default.
• W2023931269 hasConceptScore W2023931269C113217602 @default.
• W2023931269 hasConceptScore W2023931269C126322002 @default.
• W2023931269 hasConceptScore W2023931269C134018914 @default.
• W2023931269 hasConceptScore W2023931269C158617107 @default.

• next