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• W2023932049 endingPage "379" @default.
• W2023932049 startingPage "372" @default.
• W2023932049 abstract "The intrauterine environment is characterized by a Th2 dominance during pregnancy, a milieu that also promotes atopic allergy. The aim of this study was to compare the presence of CD30, a molecule associated with Th2 related disorders such as atopic allergy, and its ligand (CD30L) in placenta in order to investigate if the placenta environment differs between atopic and non-atopic women. Serum concentrations of soluble CD30 (sCD30) from the mothers and their newborns were also elucidated. There were no differences in the immunohistochemical expression of CD30 and CD30L in placenta from atopic (n=28) compared with non-atopic (n=37) women. CD30 was expressed on the decidual stromal cells alone, while CD30L, previously not described in placenta, was detected on macrophage-like HLA-DR(+) cells throughout the mesenchymal chorionic villi. Serum sCD30 in atopic mothers was significantly elevated compared with serum sCD30 in non-atopic mothers (P< 0.05), while sCD30 levels in cord blood were similar in both groups independently of maternal atopic heredity. We suggest that sCD30 in cord blood and CD30 expression by decidual cells may reflect the Th2 environment surrounding the fetus, and both CD30 and CD30L could have immune regulatory functions in placenta." @default.
• W2023932049 created "2016-06-24" @default.
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• W2023932049 date "2001-04-01" @default.
• W2023932049 modified "2023-10-10" @default.
• W2023932049 title "Presence of CD30+and CD30L+Cells in Human Placenta and Soluble CD30 Levels in Cord Blood are Independent of Maternal Atopy" @default.
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• W2023932049 doi "https://doi.org/10.1053/plac.2000.0619" @default.
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