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- W2023937546 abstract "Chemical biology relies on effective synthetic chemistry for building molecules to probe and modulate biological function. Olefin metathesis in organic solvents is a valuable addition to this armamentarium, and developments during the previous decade are enabling metathesis in aqueous solvents for the manipulation of biomolecules. Functional group-tolerant ruthenium metathesis catalysts modified with charged moieties or hydrophilic polymers are soluble and active in water, enabling ring-opening metathesis polymerization, cross metathesis, and ring-closing metathesis. Alternatively, conventional hydrophobic ruthenium complexes catalyze a similar array of metathesis reactions in mixtures of water and organic solvents. This strategy has enabled cross metathesis on the surface of a protein. Continuing developments in catalyst design and methodology will popularize the bioorthogonal reactivity of metathesis." @default.
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- W2023937546 date "2008-12-01" @default.
- W2023937546 modified "2023-10-18" @default.
- W2023937546 title "Olefin metathesis for chemical biology" @default.
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- W2023937546 doi "https://doi.org/10.1016/j.cbpa.2008.09.022" @default.
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