Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023940104> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2023940104 endingPage "22" @default.
- W2023940104 startingPage "15" @default.
- W2023940104 abstract "Tolerance to B cell-mediated experimental autoimmune myasthenia gravis (EAMG), an animal model for myasthenia gravis (MG) in humans, can be achieved by nasal administration of the autoantigen acetylcholine receptor (AChR). Nasal tolerance induction requires only 1/1000 of the amount of AChR used for oral tolerance induction, but is as effective in preventing EAMG. To investigate whether nasally induced tolerance to EAMG can be influenced by nasal administration of cytokines, recombinant rat IFN-γ (total 5000 U/rat), a combination of AChR and IFN-γ or AChR alone was given nasally to Lewis rats before immunization with AChR and complete Freund's adjuvant (CFA). One additional group of rats received the same amount of AChR nasally in conjunction with IFN-γ (total 5000 U/rat) intraperitoneally. AChR given alone nasally induced effective tolerance to EAMG whereas rats receiving AChR + IFN-γ by the nasal route exhibited a similar disease pattern, and similarly escalated T and B cell responses to AChR when compared to control EAMG rats. In contrast, administration of IFN-γ ip together with AChR nasally did not affect the induction of tolerance to EAMG. IFN-γ given alone nasally did not affect clinical EAMG. This study demonstrates that nasal tolerance can be modulated by nasal administration of minute amounts of IFN-γ. Nasal administration of certain cytokines with beneficial effects might broaden the effectiveness of applying nasal tolerance as a potential therapeutic means of preventing autoimmune diseases." @default.
- W2023940104 created "2016-06-24" @default.
- W2023940104 creator A5013573000 @default.
- W2023940104 creator A5019252731 @default.
- W2023940104 creator A5028429052 @default.
- W2023940104 creator A5032733489 @default.
- W2023940104 creator A5038929762 @default.
- W2023940104 creator A5045137608 @default.
- W2023940104 creator A5084148006 @default.
- W2023940104 date "1998-04-01" @default.
- W2023940104 modified "2023-10-01" @default.
- W2023940104 title "Nasal Tolerance to Experimental Autoimmune Myasthenia Gravis: Tolerance Reversal by Nasal Administration of Minute Amounts of Interferon-γ" @default.
- W2023940104 cites W1531017810 @default.
- W2023940104 cites W1563526255 @default.
- W2023940104 cites W1975093667 @default.
- W2023940104 cites W1989760484 @default.
- W2023940104 cites W1991531286 @default.
- W2023940104 cites W1992145267 @default.
- W2023940104 cites W1993933931 @default.
- W2023940104 cites W1995393576 @default.
- W2023940104 cites W1997157937 @default.
- W2023940104 cites W2009424411 @default.
- W2023940104 cites W2013289639 @default.
- W2023940104 cites W2017153946 @default.
- W2023940104 cites W2022409502 @default.
- W2023940104 cites W2032948393 @default.
- W2023940104 cites W2035388145 @default.
- W2023940104 cites W2046621957 @default.
- W2023940104 cites W2058530324 @default.
- W2023940104 cites W2063870729 @default.
- W2023940104 cites W2070614660 @default.
- W2023940104 cites W2074238322 @default.
- W2023940104 cites W2075214453 @default.
- W2023940104 cites W2081062408 @default.
- W2023940104 cites W2100509244 @default.
- W2023940104 cites W2114412678 @default.
- W2023940104 cites W2154760595 @default.
- W2023940104 cites W2161362125 @default.
- W2023940104 cites W4295682875 @default.
- W2023940104 doi "https://doi.org/10.1006/clin.1997.4495" @default.
- W2023940104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9576006" @default.
- W2023940104 hasPublicationYear "1998" @default.
- W2023940104 type Work @default.
- W2023940104 sameAs 2023940104 @default.
- W2023940104 citedByCount "17" @default.
- W2023940104 countsByYear W20239401042013 @default.
- W2023940104 countsByYear W20239401042015 @default.
- W2023940104 crossrefType "journal-article" @default.
- W2023940104 hasAuthorship W2023940104A5013573000 @default.
- W2023940104 hasAuthorship W2023940104A5019252731 @default.
- W2023940104 hasAuthorship W2023940104A5028429052 @default.
- W2023940104 hasAuthorship W2023940104A5032733489 @default.
- W2023940104 hasAuthorship W2023940104A5038929762 @default.
- W2023940104 hasAuthorship W2023940104A5045137608 @default.
- W2023940104 hasAuthorship W2023940104A5084148006 @default.
- W2023940104 hasConcept C126322002 @default.
- W2023940104 hasConcept C134018914 @default.
- W2023940104 hasConcept C170493617 @default.
- W2023940104 hasConcept C203014093 @default.
- W2023940104 hasConcept C2777702733 @default.
- W2023940104 hasConcept C2777863537 @default.
- W2023940104 hasConcept C2778105408 @default.
- W2023940104 hasConcept C71924100 @default.
- W2023940104 hasConcept C80161118 @default.
- W2023940104 hasConcept C85663871 @default.
- W2023940104 hasConcept C8891405 @default.
- W2023940104 hasConceptScore W2023940104C126322002 @default.
- W2023940104 hasConceptScore W2023940104C134018914 @default.
- W2023940104 hasConceptScore W2023940104C170493617 @default.
- W2023940104 hasConceptScore W2023940104C203014093 @default.
- W2023940104 hasConceptScore W2023940104C2777702733 @default.
- W2023940104 hasConceptScore W2023940104C2777863537 @default.
- W2023940104 hasConceptScore W2023940104C2778105408 @default.
- W2023940104 hasConceptScore W2023940104C71924100 @default.
- W2023940104 hasConceptScore W2023940104C80161118 @default.
- W2023940104 hasConceptScore W2023940104C85663871 @default.
- W2023940104 hasConceptScore W2023940104C8891405 @default.
- W2023940104 hasIssue "1" @default.
- W2023940104 hasLocation W20239401041 @default.
- W2023940104 hasLocation W20239401042 @default.
- W2023940104 hasOpenAccess W2023940104 @default.
- W2023940104 hasPrimaryLocation W20239401041 @default.
- W2023940104 hasRelatedWork W1963919935 @default.
- W2023940104 hasRelatedWork W1979660518 @default.
- W2023940104 hasRelatedWork W2018368842 @default.
- W2023940104 hasRelatedWork W2023940104 @default.
- W2023940104 hasRelatedWork W2033472167 @default.
- W2023940104 hasRelatedWork W2034583712 @default.
- W2023940104 hasRelatedWork W2063619316 @default.
- W2023940104 hasRelatedWork W2074821979 @default.
- W2023940104 hasRelatedWork W2169225653 @default.
- W2023940104 hasRelatedWork W2414846389 @default.
- W2023940104 hasVolume "87" @default.
- W2023940104 isParatext "false" @default.
- W2023940104 isRetracted "false" @default.
- W2023940104 magId "2023940104" @default.
- W2023940104 workType "article" @default.