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- W2023940184 abstract "Plasma PAI-1 levels robustly fluctuate in a circadian manner and consequently contribute to hypofibrinolysis during the early morning. The circadian expression of PAI-1 gene is thought to be directly regulated by the circadian clock proteins such as CLOCK and BMAL1/BMAL2 which drive the endogenous biological clock. Plasma PAI-1 levels are increased in the beginning of the active phase in both diurnal humans and in nocturnal rodents, suggesting that the rhythmic PAI-1 expression is commonly indispensable for organisms. A series of our recent studies revealed that circadian clock proteins are important for hypofibrinolysis induced by metabolic disorders such as obesity and diabetes." @default.
- W2023940184 created "2016-06-24" @default.
- W2023940184 creator A5047063734 @default.
- W2023940184 date "2009-01-01" @default.
- W2023940184 modified "2023-10-16" @default.
- W2023940184 title "Plasminogen Activator Inhibitor-1 and the Circadian Clock in Metabolic Disorders" @default.
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- W2023940184 doi "https://doi.org/10.1080/10641960902822468" @default.
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