FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023942520> ?p ?o ?g. }

• W2023942520 endingPage "247" @default.
• W2023942520 startingPage "239" @default.
• W2023942520 abstract "In vitro activated human peripheral blood lymphocytes possess the receptor protein for 1 alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3). In the present study we have examined whether activated lymphocytes that occur in vivo in human thymuses and tonsils also possess receptors for 1,25(OH)2D3. Freshly isolated lymphocyte preparations, from five separate surgical specimens of thymus and tonsil, were depleted of monocytes and examined, before and after fractionation on a density gradient of Percoll, for [3H] 1,25(OH)2D3 binding by means of sucrose density gradient sedimentation, by saturation analysis of the binding, and by DNA-cellulose chromatography. The state of activation of the lymphocyte preparations was determined using [3H] thymidine incorporation, DNA and RNA quantitation (using acridine orange), and by determining the presence or absence of markers of activation (interleukin-2 receptor, transferrin receptor, and HLA-DR molecules). In both the thymic and the tonsillar lymphocyte preparations we detected a 1,25(OH)2D3-binding molecule possessing sedimentation coefficient of 3.3 S and dissociation constant of 10(-10) M as well as DNA binding capability. In thymic lymphocytes, the 1,25(OH)2D3 receptor concentration correlated positively with the number of lymphocytes expressing the transferrin receptor (r = 0.84; p less than 0.05). In addition, in both thymic and tonsillar lymphocytes the concentration of 1,25(OH)2D3 receptors correlated positively with the number of cells in the G1a phase of the cell cycle (r = 0.79, p less than 0.01, and r = 0.88, p less than 0.001 for thymic and tonsillar lymphocytes, respectively). In contrast, the 1,25(OH)2D3 receptor concentration in these preparations did not correlate with the rate of cell proliferation.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2023942520 created "2016-06-24" @default.
• W2023942520 creator A5020831797 @default.
• W2023942520 creator A5021377658 @default.
• W2023942520 creator A5025110096 @default.
• W2023942520 creator A5027587851 @default.
• W2023942520 creator A5027634434 @default.
• W2023942520 date "2009-12-03" @default.
• W2023942520 modified "2023-10-12" @default.
• W2023942520 title "1α,25-Dihydroxyvitamin D3 receptors in human thymic and tonsillar lymphocytes" @default.
• W2023942520 cites W1487064076 @default.
• W2023942520 cites W1532477467 @default.
• W2023942520 cites W1540176268 @default.
• W2023942520 cites W1548735291 @default.
• W2023942520 cites W1637823542 @default.
• W2023942520 cites W1907348909 @default.
• W2023942520 cites W1924778996 @default.
• W2023942520 cites W1965853172 @default.
• W2023942520 cites W1966237185 @default.
• W2023942520 cites W1983649348 @default.
• W2023942520 cites W1988738875 @default.
• W2023942520 cites W1990130663 @default.
• W2023942520 cites W1990273615 @default.
• W2023942520 cites W1994244606 @default.
• W2023942520 cites W1998070104 @default.
• W2023942520 cites W1999215685 @default.
• W2023942520 cites W2000356987 @default.
• W2023942520 cites W2007331929 @default.
• W2023942520 cites W2032240359 @default.
• W2023942520 cites W2036088433 @default.
• W2023942520 cites W2038879439 @default.
• W2023942520 cites W2051720313 @default.
• W2023942520 cites W2064055081 @default.
• W2023942520 cites W2070580496 @default.
• W2023942520 cites W2072791109 @default.
• W2023942520 cites W2087265330 @default.
• W2023942520 cites W2104498491 @default.
• W2023942520 cites W2109213911 @default.
• W2023942520 cites W2155826396 @default.
• W2023942520 cites W2167936032 @default.
• W2023942520 doi "https://doi.org/10.1002/jbmr.5650020311" @default.
• W2023942520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2843004" @default.
• W2023942520 hasPublicationYear "2009" @default.
• W2023942520 type Work @default.
• W2023942520 sameAs 2023942520 @default.
• W2023942520 citedByCount "28" @default.
• W2023942520 countsByYear W20239425202012 @default.
• W2023942520 crossrefType "journal-article" @default.
• W2023942520 hasAuthorship W2023942520A5020831797 @default.
• W2023942520 hasAuthorship W2023942520A5021377658 @default.
• W2023942520 hasAuthorship W2023942520A5025110096 @default.
• W2023942520 hasAuthorship W2023942520A5027587851 @default.
• W2023942520 hasAuthorship W2023942520A5027634434 @default.
• W2023942520 hasConcept C126322002 @default.
• W2023942520 hasConcept C134018914 @default.
• W2023942520 hasConcept C153911025 @default.
• W2023942520 hasConcept C170493617 @default.
• W2023942520 hasConcept C202751555 @default.
• W2023942520 hasConcept C203014093 @default.
• W2023942520 hasConcept C2777761686 @default.
• W2023942520 hasConcept C2779419017 @default.
• W2023942520 hasConcept C32264632 @default.
• W2023942520 hasConcept C48679268 @default.
• W2023942520 hasConcept C55493867 @default.
• W2023942520 hasConcept C71924100 @default.
• W2023942520 hasConcept C86803240 @default.
• W2023942520 hasConceptScore W2023942520C126322002 @default.
• W2023942520 hasConceptScore W2023942520C134018914 @default.
• W2023942520 hasConceptScore W2023942520C153911025 @default.
• W2023942520 hasConceptScore W2023942520C170493617 @default.
• W2023942520 hasConceptScore W2023942520C202751555 @default.
• W2023942520 hasConceptScore W2023942520C203014093 @default.
• W2023942520 hasConceptScore W2023942520C2777761686 @default.
• W2023942520 hasConceptScore W2023942520C2779419017 @default.
• W2023942520 hasConceptScore W2023942520C32264632 @default.
• W2023942520 hasConceptScore W2023942520C48679268 @default.
• W2023942520 hasConceptScore W2023942520C55493867 @default.
• W2023942520 hasConceptScore W2023942520C71924100 @default.
• W2023942520 hasConceptScore W2023942520C86803240 @default.
• W2023942520 hasIssue "3" @default.
• W2023942520 hasLocation W20239425201 @default.
• W2023942520 hasLocation W20239425202 @default.
• W2023942520 hasOpenAccess W2023942520 @default.
• W2023942520 hasPrimaryLocation W20239425201 @default.
• W2023942520 hasRelatedWork W2017458083 @default.
• W2023942520 hasRelatedWork W2017952994 @default.
• W2023942520 hasRelatedWork W2018615203 @default.
• W2023942520 hasRelatedWork W2064089785 @default.
• W2023942520 hasRelatedWork W2103398921 @default.
• W2023942520 hasRelatedWork W2268242317 @default.
• W2023942520 hasRelatedWork W2363820837 @default.
• W2023942520 hasRelatedWork W268102908 @default.
• W2023942520 hasRelatedWork W2993966864 @default.
• W2023942520 hasRelatedWork W4290364901 @default.
• W2023942520 hasVolume "2" @default.
• W2023942520 isParatext "false" @default.
• W2023942520 isRetracted "false" @default.
• W2023942520 magId "2023942520" @default.

• next