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• W2023942967 endingPage "2912" @default.
• W2023942967 startingPage "2907" @default.
• W2023942967 abstract "Classical swine fever virus (CSFV) causes significant losses in pig industry in many countries in Asia and Europe. The E2 glycoprotein of CSFV is the main target for neutralizing antibodies. Recently, the replicon of alphaviruses, such as Semliki Forest virus (SFV), has been developed as replicative expression vectors for gene delivery. In this study, we constructed a plasmid DNA based on SFV replicon encoding the E2 glycoprotein of CSFV and evaluated its efficacy in rabbits and pigs. The results showed that the animals immunized with the DNA vaccine developed CSFV-specific neutralizing antibodies and were protected from virulent or lethal challenge. This demonstrates that the SFV replicon-derived DNA vaccine can be a potential marker vaccine against CSFV infections." @default.
• W2023942967 created "2016-06-24" @default.
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• W2023942967 date "2007-04-01" @default.
• W2023942967 modified "2023-09-26" @default.
• W2023942967 title "A Semliki Forest virus replicon vectored DNA vaccine expressing the E2 glycoprotein of classical swine fever virus protects pigs from lethal challenge" @default.
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• W2023942967 doi "https://doi.org/10.1016/j.vaccine.2006.08.020" @default.
• W2023942967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17007970" @default.
• W2023942967 hasPublicationYear "2007" @default.
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