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- W2023951612 abstract "The Na(+)-Ca2+ exchanger is a non-ATP-dependent protein that, under steady-state conditions, extrudes Ca2+ from the interior of the cell into the extracellular space via facilitated transport. The activity of the exchanger seems to be reduced in myocardial ischemia, leading to increased intracellular Ca2+ in the ischemic heart, which can result in arrhythmia, myocardial stunning, and necrosis. In contrast, congestive heart failure and myocardial hypertrophy are associated with increased exchanger activity and a decreased inotropic state. Pharmacologic agents are being developed to modulate sodium ion levels in the cell, which could enhance or reduce sodium-calcium exchange as needed in various pathophysiologic states. At this time there are no available drugs that act specifically on the Na(+)-Ca2+ exchanger itself. The exchanger has been cloned, and inhibitory peptides of the exchanger may soon be available for possible use in treatment of congestive heart failure." @default.
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- W2023951612 date "1998-05-01" @default.
- W2023951612 modified "2023-09-28" @default.
- W2023951612 title "The Sodium-Calcium Ion Membrane Exchanger: Physiologic Significance and Pharmacologic Implications" @default.
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- W2023951612 doi "https://doi.org/10.1002/j.1552-4604.1998.tb04442.x" @default.
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