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• W2023952437 endingPage "722" @default.
• W2023952437 startingPage "704" @default.
• W2023952437 abstract "At the cellular level, the activation and transdifferentiation of quiescent hepatic stellate cells (HSC) into myofibroblasts is the key process involved in hepatic fibrogenesis that is associated with an increased and altered deposition of extracellular matrix components in the liver. The temporal sequence of molecular events associated with stellate cell activation turned out to be appropriately mimicked when HSC isolated from normal livers are cultured on uncoated plastic surface. Therefore, cultured primary cells isolated from rodents and human beings are common in vitro models in investigations addressing these issues of hepatic stellate biology and function. However, the limited supply, cost-effective isolation procedure and the ever growing need have resulted in efforts to establish immortalized stellate cell lines having the advantage of virtually unlimited access. They allow rapid screening for disease-associated factors and restrict the necessary number of animal experiments. From the first description of an immortal HSC line in 1986, a huge number of studies were conducted with these established cell lines. However, differences in morphology, growth characteristics and anomalies of chromosome number and structure make the applications of these models questionable. Here, we summarize the history and cellular characteristics of respective cell lines and discuss the differences of continuous HSC lines and their primary counterparts." @default.
• W2023952437 created "2016-06-24" @default.
• W2023952437 creator A5018663311 @default.
• W2023952437 creator A5044825212 @default.
• W2023952437 creator A5055719124 @default.
• W2023952437 date "2007-07-01" @default.
• W2023952437 modified "2023-10-01" @default.
• W2023952437 title "Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function?" @default.
• W2023952437 cites W153151629 @default.
• W2023952437 cites W1536476892 @default.
• W2023952437 cites W1576408112 @default.
• W2023952437 cites W1589761009 @default.
• W2023952437 cites W1595746305 @default.
• W2023952437 cites W1927990266 @default.
• W2023952437 cites W1963780536 @default.
• W2023952437 cites W196694067 @default.
• W2023952437 cites W1966975625 @default.
• W2023952437 cites W1968199734 @default.
• W2023952437 cites W1970485838 @default.
• W2023952437 cites W1977373639 @default.
• W2023952437 cites W1977432666 @default.
• W2023952437 cites W1978412414 @default.
• W2023952437 cites W1985686700 @default.
• W2023952437 cites W1990366406 @default.
• W2023952437 cites W1998442406 @default.
• W2023952437 cites W1998926980 @default.
• W2023952437 cites W2000287530 @default.
• W2023952437 cites W2000847852 @default.
• W2023952437 cites W2007500450 @default.
• W2023952437 cites W2009971610 @default.
• W2023952437 cites W2010715949 @default.
• W2023952437 cites W2012349920 @default.
• W2023952437 cites W2016498524 @default.
• W2023952437 cites W2020573317 @default.
• W2023952437 cites W2028527478 @default.
• W2023952437 cites W2031795728 @default.
• W2023952437 cites W2032159683 @default.
• W2023952437 cites W2033960092 @default.
• W2023952437 cites W2034705121 @default.
• W2023952437 cites W2036734843 @default.
• W2023952437 cites W2037241605 @default.
• W2023952437 cites W2039426167 @default.
• W2023952437 cites W2039619323 @default.
• W2023952437 cites W2041945052 @default.
• W2023952437 cites W2044986728 @default.
• W2023952437 cites W2051923547 @default.
• W2023952437 cites W2053048277 @default.
• W2023952437 cites W2056767166 @default.
• W2023952437 cites W2057082268 @default.
• W2023952437 cites W2059715739 @default.
• W2023952437 cites W2060487295 @default.
• W2023952437 cites W2064385829 @default.
• W2023952437 cites W2066544997 @default.
• W2023952437 cites W2068103360 @default.
• W2023952437 cites W2071244247 @default.
• W2023952437 cites W2072187322 @default.
• W2023952437 cites W2080325240 @default.
• W2023952437 cites W2083825204 @default.
• W2023952437 cites W2086609006 @default.
• W2023952437 cites W2088724129 @default.
• W2023952437 cites W2096296299 @default.
• W2023952437 cites W2105034942 @default.
• W2023952437 cites W2113624998 @default.
• W2023952437 cites W2120193663 @default.
• W2023952437 cites W2120599966 @default.
• W2023952437 cites W2122530058 @default.
• W2023952437 cites W2130460321 @default.
• W2023952437 cites W2133075668 @default.
• W2023952437 cites W2133958299 @default.
• W2023952437 cites W2136095967 @default.
• W2023952437 cites W2154663821 @default.
• W2023952437 cites W2158089810 @default.
• W2023952437 cites W2162788353 @default.
• W2023952437 cites W2163882915 @default.
• W2023952437 cites W2165062244 @default.
• W2023952437 cites W2168979869 @default.
• W2023952437 cites W2170666112 @default.
• W2023952437 cites W2179353943 @default.
• W2023952437 cites W2188009983 @default.
• W2023952437 cites W2243440920 @default.
• W2023952437 cites W2314254441 @default.
• W2023952437 cites W2361574462 @default.
• W2023952437 cites W2372877650 @default.
• W2023952437 cites W2378707201 @default.
• W2023952437 cites W2410034194 @default.
• W2023952437 cites W2415754606 @default.
• W2023952437 cites W2476542314 @default.
• W2023952437 cites W337019729 @default.
• W2023952437 cites W4210848872 @default.
• W2023952437 cites W4212985336 @default.
• W2023952437 cites W4239032711 @default.
• W2023952437 cites W4242113393 @default.
• W2023952437 cites W67122117 @default.
• W2023952437 cites W70776180 @default.
• W2023952437 doi "https://doi.org/10.1111/j.1582-4934.2007.00060.x" @default.
• W2023952437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3823251" @default.
• W2023952437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17760834" @default.
• W2023952437 hasPublicationYear "2007" @default.

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