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• W2023952978 abstract "T lymphocytes respond to foreign antigen by forming specialized junctions with antigen-presenting cells (APC) or target cells. A hypothesis is presented, illustrating the similarity between the T-cell recognition-activation process and the cell communication processes found in other organ systems, especially the nervous system. Based on data showing that a major neuronal protein, Thy-1, is also a mitogenic site on T cells, and based on predictions for the structures of the T-cell receptor (TcR) and Ia proteins, an activation model is presented as follows. 1) The T-cell receptor initiates cell-cell contact with the APC by interacting with Ia and antigen, forming an antigen-binding site. 2) Sets of adhesion molecules then bind, focusing the interacting proteins to the junctional site. One binding protein, L3/T4, binds Ia and concentrates the Ia molecules to the contact site. 3) The two-chain TcR then links together the TcR-Ia-antigen complexes, forming a linear chain of receptors which willself-associate once reaching a critical length, forming a cluster. This cluster juxtaposes associated channel subunits, the T3 membrane molecules, creating an ion channel, stimulating the T cell. 4) The MHC molecule is structurally a part of this activation complex, and therefore also forms a cluster on the APC surface, possibly activating the presenting cell. 5) Secretory products are then released into the synaptic site allowing for efficient and directed cell-cell communication. Cytolytic class-I-restricted cells use a similar pathway to focus the effect of cytolytic proteins. This analogy views neuronal communication and lymphoid recognition as evolutionary descendents of a primordial lymphocytic type of cell interaction. Un modèle d'activation des lymphocytes T est discuté; les étapes suivantes sont envisagées:o le récepteur T permet le contact avec les cellules présentant l'antigène associé à Ia; de nombreuses molécules participent alors à la stabilisation de l'interaction (exemple L3T4); l'ensemble forme un complexe qui après réarrangement forme un canal ionique qui entraîne l'activation des lymphocytes T; parallèlement, les molécules du complexe majeur d'histocompatibilité pourraient former un canal ionique activant la cellule présentant l'antigène; des produits sont libérés dans l'espace intercellulaire et assurent la communication entre les cellules impliquées. Ce modèle présente des analogies avec la synapse; cela pourrait découler d'une origine évolutive commune." @default.
• W2023952978 created "2016-06-24" @default.
• W2023952978 creator A5090056815 @default.
• W2023952978 date "1984-01-01" @default.
• W2023952978 modified "2023-10-03" @default.
• W2023952978 title "A synaptic basis for T-lymphocyte activation" @default.
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• W2023952978 doi "https://doi.org/10.1016/s0769-2625(84)81105-8" @default.
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