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- W2023953705 abstract "The aim of the study is to assess the safety of trapidil in the setting of coronary stenting and to evaluate its efficacy in reducing angiographic in-stent restenosis. One hundred eighteen patients undergoing Palmaz-Schatz stent implantation were randomly assigned to receive antiplatelet therapy using either aspirin (325 mg/d) or trapidil (400 mg/d), in combination with ticlopidine (500 mg) for the first month. At entry, both groups were comparable with regard to clinical, angiographic, and procedural characteristics. At 6-month angiographic follow-up, >50% restenosis occurred in 15 of 52 lesions (28.8%) of the aspirin group and in 14 of 47 lesions (29.8%) of the trapidil group (P = not significant, NS). At 6-month clinical follow-up, there was no difference in the two groups in the rate of adverse events (2.0% vs. 2.1%, P = NS), medication side effects (4.0% vs. 4.2%, P = NS), and peripheral vascular complications (4.0% vs. 4.2%, P = NS). In conclusion, treatment with trapidil seems to be associated with a similar incidence of stent restenosis and adverse cardiac events as compared to aspirin and could be a valuable alternative to aspirin in the setting of coronary stenting.Cathet. Cardiovasc. Intervent. 46:162–168, 1999. © 1999 Wiley-Liss, Inc." @default.
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- W2023953705 date "1999-02-01" @default.
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- W2023953705 title "A randomized comparison of trapidil (triazolopyrimidine), a platelet-derived growth factor antagonist, versus aspirin in prevention of angiographic restenosis after coronary artery Palmaz-Schatz stent implantation" @default.
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- W2023953705 doi "https://doi.org/10.1002/(sici)1522-726x(199902)46:2<162::aid-ccd10>3.0.co;2-e" @default.
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