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• W2023954015 abstract "The objective of the present study was to explore the potential of using an in situ suspension forming drug delivery system of celecoxib to provide sustained drug exposure in the joint cavity following intra-articular administration. In vitro, precipitates were formed upon addition of a 400 mg/mL solution of celecoxib in polyethylene glycol 400 (PEG 400) to phosphate buffer, pH 7.4, or synovial fluid. The in vitro release profiles of the in situ formed suspensions were characterized by an initial fast release followed by a slower constant flux. In buffer solutions, these fluxes were comparable to those determined for a preformed suspension containing celecoxib in its most stable crystal form despite the in situ formed precipitates contained a mixture of two crystal forms of celecoxib as determined by X-ray powder diffraction. In situ suspension formation in synovial fluid was subject to considerable variation. A relatively high dose of celecoxib, corresponding to 1.25 mg/kg, in the form of PEG 400 solution (400 mg/mL) was injected into the radiocarpal joint in four horses. Celecoxib was present in serum samples taken over 10 days and in the joint tissue (post mortem), strongly indicating that joint sustained celecoxib exposure can be achieved using in situ suspension formation." @default.
• W2023954015 created "2016-06-24" @default.
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• W2023954015 date "2011-10-01" @default.
• W2023954015 modified "2023-09-27" @default.
• W2023954015 title "In vitro and in vivo characteristics of celecoxib in situ formed suspensions for intra-articular administration" @default.
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• W2023954015 doi "https://doi.org/10.1002/jps.22630" @default.
• W2023954015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21598256" @default.
• W2023954015 hasPublicationYear "2011" @default.
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