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• W2023954525 abstract "Proper chromosome segregation in mitosis relies on correct kinetochore-microtubule (KT-MT) interactions. The KT initially interacts with the lateral surface of a single MT (lateral attachment) extending from a spindle pole and is subsequently anchored at the plus end of the MT (end-on attachment) [1Tanaka T.U. Kinetochore-microtubule interactions: Steps towards bi-orientation.EMBO J. 2010; 29: 4070-4082Crossref PubMed Scopus (93) Google Scholar]. The conversion from lateral to end-on attachment is crucial because end-on attachment is more robust [2Grishchuk E.L. Molodtsov M.I. Ataullakhanov F.I. McIntosh J.R. Force production by disassembling microtubules.Nature. 2005; 438: 384-388Crossref PubMed Scopus (209) Google Scholar, 3Tanaka K. Kitamura E. Kitamura Y. Tanaka T.U. Molecular mechanisms of microtubule-dependent kinetochore transport toward spindle poles.J. Cell Biol. 2007; 178: 269-281Crossref PubMed Scopus (131) Google Scholar, 4Joglekar A.P. Bloom K.S. Salmon E.D. Mechanisms of force generation by end-on kinetochore-microtubule attachments.Curr. Opin. Cell Biol. 2010; 22: 57-67Crossref PubMed Scopus (84) Google Scholar] and thought to be necessary to sustain KT-MT attachment when tension is applied across sister KTs upon their biorientation [1Tanaka T.U. Kinetochore-microtubule interactions: Steps towards bi-orientation.EMBO J. 2010; 29: 4070-4082Crossref PubMed Scopus (93) Google Scholar]. The mechanism for this conversion is still elusive. The Ndc80 complex is an essential component of the KT-MT interface [1Tanaka T.U. Kinetochore-microtubule interactions: Steps towards bi-orientation.EMBO J. 2010; 29: 4070-4082Crossref PubMed Scopus (93) Google Scholar, 5Santaguida S. Musacchio A. The life and miracles of kinetochores.EMBO J. 2009; 28: 2511-2531Crossref PubMed Scopus (362) Google Scholar], and here we studied a role of the Ndc80 loop region, a distinct motif looping out from the coiled-coil shaft of the complex [6Maiolica A. Cittaro D. Borsotti D. Sennels L. Ciferri C. Tarricone C. Musacchio A. Rappsilber J. Structural analysis of multiprotein complexes by cross-linking, mass spectrometry, and database searching.Mol. Cell. Proteomics. 2007; 6: 2200-2211Crossref PubMed Scopus (181) Google Scholar], in Saccharomyces cerevisiae. With deletions or mutations of the loop region, the lateral KT-MT attachment occurred normally; however, subsequent conversion to end-on attachment was defective, leading to failure in sister KT biorientation. The Ndc80 loop region was required for Ndc80-Dam1 interaction and KT loading of the Dam1 complex, which in turn supported KT tethering to the dynamic MT plus end [3Tanaka K. Kitamura E. Kitamura Y. Tanaka T.U. Molecular mechanisms of microtubule-dependent kinetochore transport toward spindle poles.J. Cell Biol. 2007; 178: 269-281Crossref PubMed Scopus (131) Google Scholar, 7Westermann S. Wang H.W. Avila-Sakar A. Drubin D.G. Nogales E. Barnes G. The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends.Nature. 2006; 440: 565-569Crossref PubMed Scopus (223) Google Scholar]. The Ndc80 loop region, therefore, has an important role in the conversion from lateral to end-on attachment, a crucial maturation step of KT-MT interaction." @default.
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• W2023954525 date "2011-02-01" @default.
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• W2023954525 title "The Ndc80 Loop Region Facilitates Formation of Kinetochore Attachment to the Dynamic Microtubule Plus End" @default.
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