FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023954983> ?p ?o ?g. }

• W2023954983 endingPage "1239" @default.
• W2023954983 startingPage "1225" @default.
• W2023954983 abstract "Whereas early cytokinesis events have been relatively well studied, little is known about its final stage, abscission. The Cdc14 phosphatase is involved in the regulation of multiple cell cycle events, and in all systems studied Cdc14 misexpression leads to cytokinesis defects. In this work, we have cloned two CDC14 cDNA from Xenopus, including a previously unreported CDC14B homologue. We use Xenopus and human cell lines and demonstrate that localization of Cdc14 proteins is independent of both cell-type and species specificity. Ectopically expressed XCdc14A is centrosomal in interphase and localizes to the midbody in cytokinesis. By using XCdc14A misregulation, we confirm its control over different cell cycle events and unravel new functions during abscission. XCdc14A regulates the G1/S and G2/M transitions. We show that Cdc25 is an in vitro substrate for XCdc14A and might be its target at the G2/M transition. Upregulated wild-type or phosphatase-dead XCdc14A arrest cells in a late stage of cytokinesis, connected by thin cytoplasmic bridges. It does not interfere with central spindle formation, nor with the relocalization of passenger protein and centralspindlin complexes to the midbody. We demonstrate that XCdc14A upregulation prevents targeting of exocyst and SNARE complexes to the midbody, both essential for abscission to occur." @default.
• W2023954983 created "2016-06-24" @default.
• W2023954983 creator A5009481547 @default.
• W2023954983 creator A5025876236 @default.
• W2023954983 creator A5062385342 @default.
• W2023954983 creator A5080917134 @default.
• W2023954983 creator A5082152177 @default.
• W2023954983 creator A5085910432 @default.
• W2023954983 date "2007-04-01" @default.
• W2023954983 modified "2023-09-25" @default.
• W2023954983 title "Regulation of multiple cell cycle events by Cdc14 homologues in vertebrates" @default.
• W2023954983 cites W1493317669 @default.
• W2023954983 cites W1522784058 @default.
• W2023954983 cites W1526209674 @default.
• W2023954983 cites W1595083713 @default.
• W2023954983 cites W171936907 @default.
• W2023954983 cites W1906393634 @default.
• W2023954983 cites W1935003487 @default.
• W2023954983 cites W1967163876 @default.
• W2023954983 cites W1967869559 @default.
• W2023954983 cites W1968268257 @default.
• W2023954983 cites W1976580712 @default.
• W2023954983 cites W1981323014 @default.
• W2023954983 cites W1987767376 @default.
• W2023954983 cites W1991444138 @default.
• W2023954983 cites W1994821070 @default.
• W2023954983 cites W1999077006 @default.
• W2023954983 cites W2001583662 @default.
• W2023954983 cites W2001947684 @default.
• W2023954983 cites W2002344928 @default.
• W2023954983 cites W2004006939 @default.
• W2023954983 cites W2012532095 @default.
• W2023954983 cites W2021110902 @default.
• W2023954983 cites W2024451315 @default.
• W2023954983 cites W2030645367 @default.
• W2023954983 cites W2051948962 @default.
• W2023954983 cites W2056362544 @default.
• W2023954983 cites W2062780666 @default.
• W2023954983 cites W2065197658 @default.
• W2023954983 cites W2065876736 @default.
• W2023954983 cites W2067642644 @default.
• W2023954983 cites W2074192853 @default.
• W2023954983 cites W2074838372 @default.
• W2023954983 cites W2081184903 @default.
• W2023954983 cites W2091912506 @default.
• W2023954983 cites W2108385750 @default.
• W2023954983 cites W2114282435 @default.
• W2023954983 cites W2117571939 @default.
• W2023954983 cites W2119023421 @default.
• W2023954983 cites W2125247503 @default.
• W2023954983 cites W2131266367 @default.
• W2023954983 cites W2132592231 @default.
• W2023954983 cites W2140468006 @default.
• W2023954983 cites W2145683104 @default.
• W2023954983 cites W2149730011 @default.
• W2023954983 cites W2153790258 @default.
• W2023954983 cites W2154019163 @default.
• W2023954983 cites W2156020025 @default.
• W2023954983 cites W2156054772 @default.
• W2023954983 cites W2160274984 @default.
• W2023954983 cites W2162606553 @default.
• W2023954983 cites W2181852064 @default.
• W2023954983 cites W935855719 @default.
• W2023954983 doi "https://doi.org/10.1016/j.yexcr.2006.12.022" @default.
• W2023954983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17292885" @default.
• W2023954983 hasPublicationYear "2007" @default.
• W2023954983 type Work @default.
• W2023954983 sameAs 2023954983 @default.
• W2023954983 citedByCount "29" @default.
• W2023954983 countsByYear W20239549832012 @default.
• W2023954983 countsByYear W20239549832013 @default.
• W2023954983 countsByYear W20239549832018 @default.
• W2023954983 countsByYear W20239549832020 @default.
• W2023954983 crossrefType "journal-article" @default.
• W2023954983 hasAuthorship W2023954983A5009481547 @default.
• W2023954983 hasAuthorship W2023954983A5025876236 @default.
• W2023954983 hasAuthorship W2023954983A5062385342 @default.
• W2023954983 hasAuthorship W2023954983A5080917134 @default.
• W2023954983 hasAuthorship W2023954983A5082152177 @default.
• W2023954983 hasAuthorship W2023954983A5085910432 @default.
• W2023954983 hasConcept C1491633281 @default.
• W2023954983 hasConcept C164265269 @default.
• W2023954983 hasConcept C179411191 @default.
• W2023954983 hasConcept C29537977 @default.
• W2023954983 hasConcept C45472230 @default.
• W2023954983 hasConcept C53420372 @default.
• W2023954983 hasConcept C54355233 @default.
• W2023954983 hasConcept C6391034 @default.
• W2023954983 hasConcept C84815855 @default.
• W2023954983 hasConcept C85813293 @default.
• W2023954983 hasConcept C86803240 @default.
• W2023954983 hasConcept C95444343 @default.
• W2023954983 hasConcept C99705001 @default.
• W2023954983 hasConceptScore W2023954983C1491633281 @default.
• W2023954983 hasConceptScore W2023954983C164265269 @default.
• W2023954983 hasConceptScore W2023954983C179411191 @default.
• W2023954983 hasConceptScore W2023954983C29537977 @default.
• W2023954983 hasConceptScore W2023954983C45472230 @default.

• next