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- W2023956551 abstract "Alzheimer's disease (AD) is a neurodegenerative disease hallmarked by extracellular Aβ(1-42) containing plaques, and intracellular neurofibrillary tangles (NFT) containing hyperphosphorylated tau protein. Progressively, memory deficits and cognitive disabilities start to occur as these hallmarks affect hippocampus and frontal cortex, regions highly involved in memory. Connective tissue growth factor (CTGF) expression, which is high in the vicinity of Aβ plaques and NFTs, was found to influence γ-secretase activity, the molecular crux in Aβ(1-42) production. Tauroursodeoxycholic acid (TUDCA) is an endogenous bile acid that downregulates CTGF expression in hepatocytes and has been shown to possess therapeutic efficacy in neurodegenerative models. To investigate the possible in vivo therapeutic effects of TUDCA, we provided 0.4% TUDCA-supplemented food to APP/PS1 mice, a well-established AD mouse model. Six months of TUDCA supplementation prevented the spatial, recognition and contextual memory defects observed in APP/PS1 mice at 8 months of age. Furthermore, TUDCA-supplemented APP/PS1 mice displayed reduced hippocampal and prefrontal amyloid deposition. These effects of TUDCA supplementation suggest a novel mechanistic route for Alzheimer therapeutics." @default.
- W2023956551 created "2016-06-24" @default.
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- W2023956551 date "2013-02-01" @default.
- W2023956551 modified "2023-09-27" @default.
- W2023956551 title "Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice" @default.
- W2023956551 cites W143415333 @default.
- W2023956551 cites W1532762518 @default.
- W2023956551 cites W1611720630 @default.
- W2023956551 cites W1675105744 @default.
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- W2023956551 cites W1972364189 @default.
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- W2023956551 cites W1977040584 @default.
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- W2023956551 cites W1998016856 @default.
- W2023956551 cites W1998905522 @default.
- W2023956551 cites W2001210466 @default.
- W2023956551 cites W2001682194 @default.
- W2023956551 cites W2004381553 @default.
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- W2023956551 cites W2025561374 @default.
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- W2023956551 doi "https://doi.org/10.1016/j.nbd.2012.09.003" @default.
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