Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023957032> ?p ?o ?g. }
- W2023957032 endingPage "2384" @default.
- W2023957032 startingPage "2378" @default.
- W2023957032 abstract "Cell-cell adhesion is essential for many immunological functions and is believed to be important in the regulation of hematopoiesis. Adhesive interactions between human endothelial cells and megakaryocytes were characterized in vitro using the CMK megakaryocytic cell line as well as marrow megakaryocytes. Although there was no adhesion between unactivated human umbilical vein endothelial cells (HUVEC) and megakaryocytes, treatment of HUVEC with inflammatory cytokines such as IL-1 beta, tumor necrosis factor alpha, INF-gamma, or the phorbol ester phorbol myristate acetate (PMA) resulted in a time- and dose-dependent increase in adhesion. Stimulation of marrow megakaryocytes or CMK cells with the cytokines IL-1 beta, GM-CSF, IL-6, IL-3, or PMA augmented their adhesion to endothelium. Monoclonal antibodies against the LFA-1 subunit of the leukocyte adherence complex CD18 inhibited the binding of marrow megakaryocytes or CMK cells to HUVEC. Adhesion blocking experiments also demonstrated that the VLA-4/VCAM-1 pathway was important for megakaryocyte attachment to HUVEC. Adhesion promoted maturation of megakaryocytic cells as measured by increased expression of glycoproteins GpIb and GpIIb/IIIa and by increased DNA content. These observations suggest that alterations in megakaryocyte adhesion may occur during inflammatory conditions, mediated by certain cytokines, resulting in augmented megakaryocyte maturation." @default.
- W2023957032 created "2016-06-24" @default.
- W2023957032 creator A5037532465 @default.
- W2023957032 creator A5049975962 @default.
- W2023957032 creator A5065089613 @default.
- W2023957032 creator A5073353369 @default.
- W2023957032 creator A5078272808 @default.
- W2023957032 date "1993-06-01" @default.
- W2023957032 modified "2023-09-25" @default.
- W2023957032 title "Characterization of adhesive interactions between human endothelial cells and megakaryocytes." @default.
- W2023957032 cites W1483051496 @default.
- W2023957032 cites W1483915559 @default.
- W2023957032 cites W1488601882 @default.
- W2023957032 cites W1525390456 @default.
- W2023957032 cites W1742452979 @default.
- W2023957032 cites W1803681061 @default.
- W2023957032 cites W1811625932 @default.
- W2023957032 cites W1864286509 @default.
- W2023957032 cites W1966286149 @default.
- W2023957032 cites W1966482743 @default.
- W2023957032 cites W1976108361 @default.
- W2023957032 cites W1985572665 @default.
- W2023957032 cites W1996183705 @default.
- W2023957032 cites W2001720727 @default.
- W2023957032 cites W2004273103 @default.
- W2023957032 cites W2022977480 @default.
- W2023957032 cites W2023487115 @default.
- W2023957032 cites W2026075546 @default.
- W2023957032 cites W2029231027 @default.
- W2023957032 cites W2031209863 @default.
- W2023957032 cites W2033318972 @default.
- W2023957032 cites W2036145275 @default.
- W2023957032 cites W2045223151 @default.
- W2023957032 cites W2051321857 @default.
- W2023957032 cites W2055090102 @default.
- W2023957032 cites W2057905142 @default.
- W2023957032 cites W2062582674 @default.
- W2023957032 cites W2062926268 @default.
- W2023957032 cites W2065051915 @default.
- W2023957032 cites W2083217753 @default.
- W2023957032 cites W2086487142 @default.
- W2023957032 cites W2110673870 @default.
- W2023957032 cites W2117895485 @default.
- W2023957032 cites W2135121318 @default.
- W2023957032 cites W2150595969 @default.
- W2023957032 cites W2157603347 @default.
- W2023957032 cites W2169318446 @default.
- W2023957032 cites W2174557896 @default.
- W2023957032 cites W227781810 @default.
- W2023957032 cites W2405750565 @default.
- W2023957032 cites W2413825876 @default.
- W2023957032 cites W244034654 @default.
- W2023957032 doi "https://doi.org/10.1172/jci116470" @default.
- W2023957032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/443295" @default.
- W2023957032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8514851" @default.
- W2023957032 hasPublicationYear "1993" @default.
- W2023957032 type Work @default.
- W2023957032 sameAs 2023957032 @default.
- W2023957032 citedByCount "82" @default.
- W2023957032 countsByYear W20239570322013 @default.
- W2023957032 countsByYear W20239570322014 @default.
- W2023957032 countsByYear W20239570322015 @default.
- W2023957032 countsByYear W20239570322016 @default.
- W2023957032 countsByYear W20239570322017 @default.
- W2023957032 countsByYear W20239570322018 @default.
- W2023957032 countsByYear W20239570322019 @default.
- W2023957032 countsByYear W20239570322020 @default.
- W2023957032 countsByYear W20239570322021 @default.
- W2023957032 countsByYear W20239570322022 @default.
- W2023957032 countsByYear W20239570322023 @default.
- W2023957032 crossrefType "journal-article" @default.
- W2023957032 hasAuthorship W2023957032A5037532465 @default.
- W2023957032 hasAuthorship W2023957032A5049975962 @default.
- W2023957032 hasAuthorship W2023957032A5065089613 @default.
- W2023957032 hasAuthorship W2023957032A5073353369 @default.
- W2023957032 hasAuthorship W2023957032A5078272808 @default.
- W2023957032 hasBestOaLocation W20239570321 @default.
- W2023957032 hasConcept C109159458 @default.
- W2023957032 hasConcept C123012128 @default.
- W2023957032 hasConcept C153911025 @default.
- W2023957032 hasConcept C16224149 @default.
- W2023957032 hasConcept C178790620 @default.
- W2023957032 hasConcept C17991360 @default.
- W2023957032 hasConcept C183521119 @default.
- W2023957032 hasConcept C185592680 @default.
- W2023957032 hasConcept C202751555 @default.
- W2023957032 hasConcept C203014093 @default.
- W2023957032 hasConcept C2777411675 @default.
- W2023957032 hasConcept C2779705218 @default.
- W2023957032 hasConcept C28328180 @default.
- W2023957032 hasConcept C55493867 @default.
- W2023957032 hasConcept C84416704 @default.
- W2023957032 hasConcept C85789140 @default.
- W2023957032 hasConcept C86803240 @default.
- W2023957032 hasConcept C95444343 @default.
- W2023957032 hasConceptScore W2023957032C109159458 @default.
- W2023957032 hasConceptScore W2023957032C123012128 @default.
- W2023957032 hasConceptScore W2023957032C153911025 @default.