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- W2023959986 abstract "The ShB ΔN mutant T449A undergoes C-type inactivation after depolarization within ∼100 ms in external solutions containing 2-4 mM Ca2+ and 0 K+. Raising external Ca2+ to 40 mM, reduces peak IK for a single pulse to ∼ 20%, and virtually eliminates IK with steady pulsing at 0.1 Hz. The effect of Ca2+is reversible. Raising external K+ to 5-20 mM (in 40 mM Ca2+) largely restores IK. How is Ca2+ suppression and K+ restoration of IK explained? Ca2+ blocks inward IK through an open channel strongly at negative voltages. We propose that Ca2+ competes with K+ at Site0 (just outside the selectivity filter) where K+ is strongly favored, but Ca2+ occupancy is enhanced at negative voltages. Ca2+ occupancy of Site0 strongly reduces K+ access to and occupancy of Site1 (outermost site of the filter), allowing repulsion among the carbonyls of Site1 to dilate this site, causing C-type inactivation. La3+ has almost the same crystal radius as Ca2+, and is much more potent in suppressing IK: with 10 μM La3+ externally, IK of T449A is largely eliminated (reversibly). We postulate that trivalent La3+ has high affinity for Site0. Neither Ca2+ nor La3+ has strong effects on T449V, which does not exhibit C-type inactivation." @default.
- W2023959986 created "2016-06-24" @default.
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- W2023959986 date "2014-01-01" @default.
- W2023959986 modified "2023-09-26" @default.
- W2023959986 title "Enhancement of C-Type Inactivation by External Ca2+ and La3+" @default.
- W2023959986 doi "https://doi.org/10.1016/j.bpj.2013.11.2995" @default.
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