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- W2023961140 abstract "The effect of a thromboxane A2 (TXA2) receptor antagonist, On-579, on experimental allergic skin and airway reactions was studied in vivo. ON-579 at doses of 1 and 20 mg/kg clearly inhibited U-46619-induced increases in respiratory resistance (Rrs) in guinea pigs. ON-579 at doses of 1, 20 and 50 mg/kg inhibited the aerosolized antigen-induced biphasic increase in Rrs in guinea pigs. Moreover, ON-579 clearly inhibited repeated aeroantigen-induced airway hyperreactivity in guinea pigs. ON-579, however, did not have any significant effects on allergic cutaneous reactions in rats. These results suggest that ON-579 is a relatively selective TXA2 antagonist, especially in the airways, and indicate the efficacy of ON-579 on antigen-induced increase in airway resistance and antigen-induced airway hyperreactivity in guinea pigs." @default.
- W2023961140 created "2016-06-24" @default.
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- W2023961140 date "1995-08-01" @default.
- W2023961140 modified "2023-09-23" @default.
- W2023961140 title "The effect of a TXA2 receptor antagonist ON-579 on experimental allergic reactions" @default.
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- W2023961140 doi "https://doi.org/10.1016/0952-3278(95)90139-6" @default.
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