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• W2023961866 abstract "Whereas native and recombinant S100A1 inhibited GFAP assembly, a truncated S100A1 lacking the last six C-terminal residues (Phe88-Ser93) (S100A1Δ88-93) proved unable to do so. The inhibitory effects of native and recombinant S100A1 on GFAP assembly were blocked by both TRTK-12, a synthetic peptide derived from the α-subunit of the actin capping protein, CapZ, and a synthetic peptide derived from the tumor-suppressor protein, p53, in a dose-dependent manner. By fluorescent spectroscopy, TRTK-12 and the p53 peptide, like GFAP and tubulin, caused a dose- and Ca2+-dependent blue-shift of the fluorescence maximum of acrylodan-S100A1. In contrast, GFAP, tubulin, TRTK-12, or the p53 peptide caused no significant changes in the fluorescence spectrum of acrylodan-S100A1Δ88-93. By chemical crosslinking, both TRTK-12 and the p53 peptide strongly reduced or blocked the formation of GFAP-S100A1 or tubulin-S100A1 complexes, respectively, and S100A1Δ88-93 was unable to complex with tubulin, whereas a remarkably reduced complexation of GFAP with the truncated protein was observed. All the above observations show that the C-terminal extension of S100A1 is an essential part of the S100A1 site implicated in the recognition of GFAP, tubulin, p53, and the α-subunit of CapZ." @default.
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• W2023961866 date "1999-01-01" @default.
• W2023961866 modified "2023-09-30" @default.
• W2023961866 title "Role of the C-Terminal Extension in the Interaction of S100A1 with GFAP, Tubulin, the S100A1- and S100B-Inhibitory Peptide, TRTK-12, and a Peptide Derived from p53, and the S100A1 Inhibitory Effect on GFAP Polymerization" @default.
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• W2023961866 doi "https://doi.org/10.1006/bbrc.1998.9881" @default.
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