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- W2023961868 abstract "This study is directed towards the evaluation of synthetic compounds having the capacity to inhibitthe metabolism of androgens within the rat ventral prostate gland. Two antiandrogens, 186.659 (A) and L598.229 (B) were investigated to determine their effect on the above enzyme activities. Compound A, possessing a chemical structure similar to testosterone, was found to be a potent inhibitor of 5α-reductase activity; the inhibition was of the competitive type and the Ki obtained was 5 × 10−8 M. Compound B, with a ring A structure identical to dihydrotestosterone, was found to be a strong competitive inhibitor of 3α-hydroxysteroid dehydrogenase with a Ki of 2.5 × 10−6M." @default.
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- W2023961868 date "1977-11-01" @default.
- W2023961868 modified "2023-10-10" @default.
- W2023961868 title "Inhibition of prostatic 5α-reductase and 3α-hydroxysteroid dehydrogenase by two antiandrogens" @default.
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- W2023961868 doi "https://doi.org/10.1016/0022-4731(77)90065-6" @default.
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