Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023962283> ?p ?o ?g. }
- W2023962283 endingPage "1164" @default.
- W2023962283 startingPage "1151" @default.
- W2023962283 abstract "Angiogenesis is a hallmark of malignant neoplasias, as the formation of new blood vessels is required for tumors to acquire oxygen and nutrients essential for their continued growth and metastasis. However, the signaling pathways leading to tumor vascularization are not fully understood. Here, using a transplantable mouse tumor model, we have demonstrated that endogenous IFN-β inhibits tumor angiogenesis through repression of genes encoding proangiogenic and homing factors in tumor-infiltrating neutrophils. We determined that IFN-β–deficient mice injected with B16F10 melanoma or MCA205 fibrosarcoma cells developed faster-growing tumors with better-developed blood vessels than did syngeneic control mice. These tumors displayed enhanced infiltration by CD11b+Gr1+ neutrophils expressing elevated levels of the genes encoding the proangiogenic factors VEGF and MMP9 and the homing receptor CXCR4. They also expressed higher levels of the transcription factors c-myc and STAT3, known regulators of VEGF, MMP9, and CXCR4. In vitro, treatment of these tumor-infiltrating neutrophils with low levels of IFN-β restored expression of proangiogenic factors to control levels. Moreover, depletion of these neutrophils inhibited tumor growth in both control and IFN-β–deficient mice. We therefore suggest that constitutively produced endogenous IFN-β is an important mediator of innate tumor surveillance. Further, we believe our data help to explain the therapeutic effect of IFN treatment during the early stages of cancer development." @default.
- W2023962283 created "2016-06-24" @default.
- W2023962283 creator A5014914850 @default.
- W2023962283 creator A5022062058 @default.
- W2023962283 creator A5031649379 @default.
- W2023962283 creator A5032178490 @default.
- W2023962283 creator A5050358121 @default.
- W2023962283 date "2010-04-01" @default.
- W2023962283 modified "2023-10-18" @default.
- W2023962283 title "Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model" @default.
- W2023962283 cites W1480357432 @default.
- W2023962283 cites W1485875137 @default.
- W2023962283 cites W1966726954 @default.
- W2023962283 cites W1969103696 @default.
- W2023962283 cites W1975307585 @default.
- W2023962283 cites W1975764372 @default.
- W2023962283 cites W1976687204 @default.
- W2023962283 cites W1976767301 @default.
- W2023962283 cites W1982027307 @default.
- W2023962283 cites W1988924112 @default.
- W2023962283 cites W1989598674 @default.
- W2023962283 cites W1998307883 @default.
- W2023962283 cites W2000000541 @default.
- W2023962283 cites W2000844825 @default.
- W2023962283 cites W2002722426 @default.
- W2023962283 cites W2015878901 @default.
- W2023962283 cites W2021268612 @default.
- W2023962283 cites W2034269086 @default.
- W2023962283 cites W2037697865 @default.
- W2023962283 cites W2039045803 @default.
- W2023962283 cites W2040617651 @default.
- W2023962283 cites W2047948762 @default.
- W2023962283 cites W2052313621 @default.
- W2023962283 cites W2058529396 @default.
- W2023962283 cites W2059441259 @default.
- W2023962283 cites W2060991883 @default.
- W2023962283 cites W2072178451 @default.
- W2023962283 cites W2073604143 @default.
- W2023962283 cites W2078919455 @default.
- W2023962283 cites W2078919511 @default.
- W2023962283 cites W2080196370 @default.
- W2023962283 cites W2082889122 @default.
- W2023962283 cites W2083916710 @default.
- W2023962283 cites W2090843484 @default.
- W2023962283 cites W2092409918 @default.
- W2023962283 cites W2094918348 @default.
- W2023962283 cites W2102947626 @default.
- W2023962283 cites W2111343488 @default.
- W2023962283 cites W2111678165 @default.
- W2023962283 cites W2114736117 @default.
- W2023962283 cites W2115743823 @default.
- W2023962283 cites W2115820607 @default.
- W2023962283 cites W2116018770 @default.
- W2023962283 cites W2119705958 @default.
- W2023962283 cites W2120250750 @default.
- W2023962283 cites W2120399781 @default.
- W2023962283 cites W2123373938 @default.
- W2023962283 cites W2123684807 @default.
- W2023962283 cites W2126767360 @default.
- W2023962283 cites W2129311237 @default.
- W2023962283 cites W2133444342 @default.
- W2023962283 cites W2134068241 @default.
- W2023962283 cites W2135270910 @default.
- W2023962283 cites W2144637577 @default.
- W2023962283 cites W2147071344 @default.
- W2023962283 cites W2151463001 @default.
- W2023962283 cites W2154024950 @default.
- W2023962283 cites W2154229564 @default.
- W2023962283 cites W2154353368 @default.
- W2023962283 cites W2155850103 @default.
- W2023962283 cites W2156279609 @default.
- W2023962283 cites W2157580991 @default.
- W2023962283 cites W2158743409 @default.
- W2023962283 cites W2159138041 @default.
- W2023962283 cites W2159913536 @default.
- W2023962283 cites W2163247322 @default.
- W2023962283 cites W2164925241 @default.
- W2023962283 cites W2174193227 @default.
- W2023962283 cites W97158386 @default.
- W2023962283 doi "https://doi.org/10.1172/jci37223" @default.
- W2023962283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2846036" @default.
- W2023962283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20237412" @default.
- W2023962283 hasPublicationYear "2010" @default.
- W2023962283 type Work @default.
- W2023962283 sameAs 2023962283 @default.
- W2023962283 citedByCount "441" @default.
- W2023962283 countsByYear W20239622832012 @default.
- W2023962283 countsByYear W20239622832013 @default.
- W2023962283 countsByYear W20239622832014 @default.
- W2023962283 countsByYear W20239622832015 @default.
- W2023962283 countsByYear W20239622832016 @default.
- W2023962283 countsByYear W20239622832017 @default.
- W2023962283 countsByYear W20239622832018 @default.
- W2023962283 countsByYear W20239622832019 @default.
- W2023962283 countsByYear W20239622832020 @default.
- W2023962283 countsByYear W20239622832021 @default.
- W2023962283 countsByYear W20239622832022 @default.
- W2023962283 countsByYear W20239622832023 @default.