Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023963260> ?p ?o ?g. }
- W2023963260 endingPage "203" @default.
- W2023963260 startingPage "189" @default.
- W2023963260 abstract "Efforts to determine and understand the causes of autism are currently hampered by a large disconnect between recent molecular genetics findings that are associated with the condition and the core behavioral symptoms that define the condition. In this perspective piece, we propose a systems biology framework to bridge that gap between genes and symptoms. The framework focuses on basic mechanisms of socialization that are highly-conserved in evolution and are early-emerging in development. By conceiving of these basic mechanisms of socialization as quantitative endophenotypes, we hope to connect genes and behavior in autism through integrative studies of neurodevelopmental, behavioral, and epigenetic changes. These changes both lead to and are led by the accomplishment of specific social adaptive tasks in a typical infant's life. However, based on recent research that indicates that infants later diagnosed with autism fail to accomplish at least some of these tasks, we suggest that a narrow developmental period, spanning critical transitions from reflexive, subcortically-controlled visual behavior to interactional, cortically-controlled and social visual behavior be prioritized for future study. Mapping epigenetic, neural, and behavioral changes that both drive and are driven by these early transitions may shed a bright light on the pathogenesis of autism." @default.
- W2023963260 created "2016-06-24" @default.
- W2023963260 creator A5011990288 @default.
- W2023963260 creator A5014193008 @default.
- W2023963260 creator A5068428667 @default.
- W2023963260 date "2015-03-01" @default.
- W2023963260 modified "2023-10-17" @default.
- W2023963260 title "Social visual engagement in infants and toddlers with autism: Early developmental transitions and a model of pathogenesis" @default.
- W2023963260 cites W1497271710 @default.
- W2023963260 cites W1559742681 @default.
- W2023963260 cites W1603307924 @default.
- W2023963260 cites W1645143732 @default.
- W2023963260 cites W1826788859 @default.
- W2023963260 cites W1861186579 @default.
- W2023963260 cites W1911605042 @default.
- W2023963260 cites W193654215 @default.
- W2023963260 cites W1965008419 @default.
- W2023963260 cites W1968165122 @default.
- W2023963260 cites W1970805818 @default.
- W2023963260 cites W1971708895 @default.
- W2023963260 cites W1972501089 @default.
- W2023963260 cites W1974195095 @default.
- W2023963260 cites W1974231312 @default.
- W2023963260 cites W1975288387 @default.
- W2023963260 cites W1975455171 @default.
- W2023963260 cites W1978572281 @default.
- W2023963260 cites W1979877610 @default.
- W2023963260 cites W1980794290 @default.
- W2023963260 cites W1981461861 @default.
- W2023963260 cites W1987548747 @default.
- W2023963260 cites W1987594719 @default.
- W2023963260 cites W1988011192 @default.
- W2023963260 cites W1988946938 @default.
- W2023963260 cites W1989346891 @default.
- W2023963260 cites W1989923863 @default.
- W2023963260 cites W1993793414 @default.
- W2023963260 cites W1995730009 @default.
- W2023963260 cites W1995787205 @default.
- W2023963260 cites W1996068081 @default.
- W2023963260 cites W1999072070 @default.
- W2023963260 cites W1999595872 @default.
- W2023963260 cites W2000916459 @default.
- W2023963260 cites W2003064434 @default.
- W2023963260 cites W2004618905 @default.
- W2023963260 cites W2005515221 @default.
- W2023963260 cites W2010277019 @default.
- W2023963260 cites W2014069837 @default.
- W2023963260 cites W2014710800 @default.
- W2023963260 cites W2015169295 @default.
- W2023963260 cites W2015213948 @default.
- W2023963260 cites W2017481703 @default.
- W2023963260 cites W2018818357 @default.
- W2023963260 cites W2019664375 @default.
- W2023963260 cites W2020472669 @default.
- W2023963260 cites W2021585234 @default.
- W2023963260 cites W2021976298 @default.
- W2023963260 cites W2022689242 @default.
- W2023963260 cites W2022903092 @default.
- W2023963260 cites W2025471148 @default.
- W2023963260 cites W2026783279 @default.
- W2023963260 cites W2027444771 @default.
- W2023963260 cites W2027699228 @default.
- W2023963260 cites W2028813868 @default.
- W2023963260 cites W2030461288 @default.
- W2023963260 cites W2031902656 @default.
- W2023963260 cites W2032771066 @default.
- W2023963260 cites W2032795835 @default.
- W2023963260 cites W2033675290 @default.
- W2023963260 cites W2034586341 @default.
- W2023963260 cites W2035269878 @default.
- W2023963260 cites W2035555783 @default.
- W2023963260 cites W2037316381 @default.
- W2023963260 cites W2040866200 @default.
- W2023963260 cites W2042297319 @default.
- W2023963260 cites W2043986349 @default.
- W2023963260 cites W2047080747 @default.
- W2023963260 cites W2047143817 @default.
- W2023963260 cites W2047560633 @default.
- W2023963260 cites W2048077272 @default.
- W2023963260 cites W2050141042 @default.
- W2023963260 cites W2051705727 @default.
- W2023963260 cites W2052192816 @default.
- W2023963260 cites W2052412604 @default.
- W2023963260 cites W2052628586 @default.
- W2023963260 cites W2053511500 @default.
- W2023963260 cites W2053626490 @default.
- W2023963260 cites W2054861476 @default.
- W2023963260 cites W2055875054 @default.
- W2023963260 cites W2057457252 @default.
- W2023963260 cites W2059361327 @default.
- W2023963260 cites W2059424124 @default.
- W2023963260 cites W2060374797 @default.
- W2023963260 cites W2064718313 @default.
- W2023963260 cites W2065063336 @default.
- W2023963260 cites W2065814251 @default.
- W2023963260 cites W2068803198 @default.
- W2023963260 cites W2073062083 @default.
- W2023963260 cites W2074414345 @default.