FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023963860> ?p ?o ?g. }

• W2023963860 endingPage "177" @default.
• W2023963860 startingPage "159" @default.
• W2023963860 abstract "We have studied the effect of denervation on the degradation of the existing junctional acetylcholine (ACh) receptors at end-plates in rat muscles. ACh receptors were labelled by injecting animals with iodinated alpha-bungarotoxin (I-alpha BT); 1 day later the left hemidiaphragm was denervated. The degradation of bound I-alpha BT in normal and denervated muscles was examined in organ culture, beginning at various times after denervation in vivo. The original, pre-labelled end-plate ACh receptors are degraded more rapidly after denervation. The rate of degradation begins to increase shortly after the nerve is cut and reaches a maximum value at about 9 days of denervation. Muscles denervated only on transfer to organ culture also show an increase in the degradation rate of bound I-alpha BT with increasing time of denervation (time in culture). In normal diaphragm muscles, the initial rate of degradation of functional ACh receptors, after correcting for non-degradative loss of I-alpha BT, is 0.0018 h-1 (t1/2 = 383 h). The maximal rate at denervated end-plates is 0.0073 h-1 (t1/2 = 94 h). For soleus, sternomastoid, plantaris and intercostal innervated muscles the apparent rate of ACh receptor degradation either in vitro or in vivo ranged from 0.0005 h-1 to 0.002 h-1. The rate of loss of bound I-alpha BT in vivo is more rapid at denervated end-plates than at innervated end-plates. For diaphragm muscles, the rates of I-alpha BT degradation measured in organ culture are able to describe the relative rates of loss of I-alpha BT from innervated and denervated muscles in vivo. At short times after labelling, a fraction (10-20%) of the I-alpha BT bound to innervated muscles is degraded more rapidly than the remaining toxin. The possibility that these I-alpha BT binding sites are degraded at the rate characteristic of extrajunctional receptors on denervated muscle fibres is discussed." @default.
• W2023963860 created "2016-06-24" @default.
• W2023963860 creator A5018567435 @default.
• W2023963860 creator A5045072394 @default.
• W2023963860 date "1983-03-01" @default.
• W2023963860 modified "2023-10-18" @default.
• W2023963860 title "Denervation increases the degradation rate of acetylcholine receptors at end-plates in vivo and in vitro." @default.
• W2023963860 cites W1569819751 @default.
• W2023963860 cites W1964242422 @default.
• W2023963860 cites W1967040054 @default.
• W2023963860 cites W1969549699 @default.
• W2023963860 cites W1971207503 @default.
• W2023963860 cites W1977208459 @default.
• W2023963860 cites W1982750499 @default.
• W2023963860 cites W1987057771 @default.
• W2023963860 cites W1988423623 @default.
• W2023963860 cites W2002301530 @default.
• W2023963860 cites W2006065111 @default.
• W2023963860 cites W2013402682 @default.
• W2023963860 cites W2015955044 @default.
• W2023963860 cites W2022279084 @default.
• W2023963860 cites W2024818313 @default.
• W2023963860 cites W2030151456 @default.
• W2023963860 cites W2034684185 @default.
• W2023963860 cites W2050237848 @default.
• W2023963860 cites W2074588270 @default.
• W2023963860 cites W2078529500 @default.
• W2023963860 cites W2084237770 @default.
• W2023963860 cites W2084497433 @default.
• W2023963860 cites W2119125561 @default.
• W2023963860 cites W2130637392 @default.
• W2023963860 cites W2133494168 @default.
• W2023963860 cites W2137937004 @default.
• W2023963860 doi "https://doi.org/10.1113/jphysiol.1983.sp014574" @default.
• W2023963860 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1198963" @default.
• W2023963860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6875905" @default.
• W2023963860 hasPublicationYear "1983" @default.
• W2023963860 type Work @default.
• W2023963860 sameAs 2023963860 @default.
• W2023963860 citedByCount "52" @default.
• W2023963860 countsByYear W20239638602014 @default.
• W2023963860 countsByYear W20239638602015 @default.
• W2023963860 countsByYear W20239638602021 @default.
• W2023963860 crossrefType "journal-article" @default.
• W2023963860 hasAuthorship W2023963860A5018567435 @default.
• W2023963860 hasAuthorship W2023963860A5045072394 @default.
• W2023963860 hasBestOaLocation W20239638601 @default.
• W2023963860 hasConcept C105702510 @default.
• W2023963860 hasConcept C121332964 @default.
• W2023963860 hasConcept C126322002 @default.
• W2023963860 hasConcept C134018914 @default.
• W2023963860 hasConcept C150903083 @default.
• W2023963860 hasConcept C157138929 @default.
• W2023963860 hasConcept C164292776 @default.
• W2023963860 hasConcept C170493617 @default.
• W2023963860 hasConcept C185592680 @default.
• W2023963860 hasConcept C207001950 @default.
• W2023963860 hasConcept C24890656 @default.
• W2023963860 hasConcept C24998067 @default.
• W2023963860 hasConcept C2775910092 @default.
• W2023963860 hasConcept C2776805190 @default.
• W2023963860 hasConcept C55493867 @default.
• W2023963860 hasConcept C71924100 @default.
• W2023963860 hasConcept C80161118 @default.
• W2023963860 hasConcept C86803240 @default.
• W2023963860 hasConceptScore W2023963860C105702510 @default.
• W2023963860 hasConceptScore W2023963860C121332964 @default.
• W2023963860 hasConceptScore W2023963860C126322002 @default.
• W2023963860 hasConceptScore W2023963860C134018914 @default.
• W2023963860 hasConceptScore W2023963860C150903083 @default.
• W2023963860 hasConceptScore W2023963860C157138929 @default.
• W2023963860 hasConceptScore W2023963860C164292776 @default.
• W2023963860 hasConceptScore W2023963860C170493617 @default.
• W2023963860 hasConceptScore W2023963860C185592680 @default.
• W2023963860 hasConceptScore W2023963860C207001950 @default.
• W2023963860 hasConceptScore W2023963860C24890656 @default.
• W2023963860 hasConceptScore W2023963860C24998067 @default.
• W2023963860 hasConceptScore W2023963860C2775910092 @default.
• W2023963860 hasConceptScore W2023963860C2776805190 @default.
• W2023963860 hasConceptScore W2023963860C55493867 @default.
• W2023963860 hasConceptScore W2023963860C71924100 @default.
• W2023963860 hasConceptScore W2023963860C80161118 @default.
• W2023963860 hasConceptScore W2023963860C86803240 @default.
• W2023963860 hasIssue "1" @default.
• W2023963860 hasLocation W20239638601 @default.
• W2023963860 hasLocation W20239638602 @default.
• W2023963860 hasLocation W20239638603 @default.
• W2023963860 hasOpenAccess W2023963860 @default.
• W2023963860 hasPrimaryLocation W20239638601 @default.
• W2023963860 hasRelatedWork W1034468122 @default.
• W2023963860 hasRelatedWork W1970010209 @default.
• W2023963860 hasRelatedWork W2007972228 @default.
• W2023963860 hasRelatedWork W2015167423 @default.
• W2023963860 hasRelatedWork W2035909636 @default.
• W2023963860 hasRelatedWork W2042056539 @default.
• W2023963860 hasRelatedWork W2079880301 @default.
• W2023963860 hasRelatedWork W2094459580 @default.
• W2023963860 hasRelatedWork W2141284133 @default.

• next