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• W2023967099 abstract "The capabilities of organisms to contend with environmental changes depend on their genes and their ability to regulate their expression. DNA-binding transcription factors (TFs) play a central role in this process, because they regulate gene expression positively and/or negatively, depending on the operator context and ligand-binding status. In this review, we summarise recent findings regarding the function and evolution of TFs in prokaryotes. We consider the abundance of TFs in bacteria and archaea, the role of DNA-binding domains and their partner domains, and the effects of duplication events in the evolution of regulatory networks. Finally, a comprehensive picture for how regulatory networks have evolved in prokaryotes is provided." @default.
• W2023967099 created "2016-06-24" @default.
• W2023967099 creator A5005750232 @default.
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• W2023967099 date "2012-09-01" @default.
• W2023967099 modified "2023-10-17" @default.
• W2023967099 title "The Repertoire of DNA-Binding Transcription Factors in Prokaryotes: Functional and Evolutionary Lessons" @default.
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• W2023967099 doi "https://doi.org/10.3184/003685012x13420097673409" @default.
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