Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023967548> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2023967548 endingPage "328" @default.
- W2023967548 startingPage "328" @default.
- W2023967548 abstract "Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid (AA) catalyzed by cytochrome P450 (CYP), have many essential biologic roles in the cardiovascular system including inhibition of apoptosis in cardiomyocytes. In the present study, we tested the potential of 8,9-EET and derivatives to protect pulmonary artery smooth muscle cells (PASMCs) from starvation induced apoptosis. We found 8,9-epoxy-eicos-11(Z)-enoic acid (8,9-EET analog (214)), but not 8,9-EET, increased cell viability, decreased activation of caspase-3 and caspase-9, and decreased TUNEL-positive cells or nuclear condensation induced by serum deprivation (SD) in PASMCs. These effects were reversed after blocking the Rho-kinase (ROCK) pathway with Y-27632 or HA-1077. Therefore, 8,9-EET analog (214) protects PASMC from serum deprivation-induced apoptosis, mediated at least in part via the ROCK pathway. Serum deprivation of PASMCs resulted in mitochondrial membrane depolarization, decreased expression of Bcl-2 and enhanced expression of Bax, all effects were reversed by 8,9-EET analog (214) in a ROCK dependent manner. Because 8,9-EET and not the 8,9-EET analog (214) protects pulmonary artery endothelial cells (PAECs), these observations suggest the potential to differentially promote apoptosis or survival with 8,9-EET or analogs in pulmonary arteries." @default.
- W2023967548 created "2016-06-24" @default.
- W2023967548 creator A5002796314 @default.
- W2023967548 creator A5045247046 @default.
- W2023967548 creator A5050978422 @default.
- W2023967548 creator A5065497261 @default.
- W2023967548 creator A5079614405 @default.
- W2023967548 date "2004-01-01" @default.
- W2023967548 modified "2023-09-30" @default.
- W2023967548 title "A case of neurilemmoma arising in the brachial plexus in association with breast cancer" @default.
- W2023967548 doi "https://doi.org/10.1016/s0344-0338(04)80673-3" @default.
- W2023967548 hasPublicationYear "2004" @default.
- W2023967548 type Work @default.
- W2023967548 sameAs 2023967548 @default.
- W2023967548 citedByCount "0" @default.
- W2023967548 crossrefType "journal-article" @default.
- W2023967548 hasAuthorship W2023967548A5002796314 @default.
- W2023967548 hasAuthorship W2023967548A5045247046 @default.
- W2023967548 hasAuthorship W2023967548A5050978422 @default.
- W2023967548 hasAuthorship W2023967548A5065497261 @default.
- W2023967548 hasAuthorship W2023967548A5079614405 @default.
- W2023967548 hasConcept C126322002 @default.
- W2023967548 hasConcept C134018914 @default.
- W2023967548 hasConcept C181199279 @default.
- W2023967548 hasConcept C185592680 @default.
- W2023967548 hasConcept C190283241 @default.
- W2023967548 hasConcept C196795494 @default.
- W2023967548 hasConcept C2778078955 @default.
- W2023967548 hasConcept C29311851 @default.
- W2023967548 hasConcept C502942594 @default.
- W2023967548 hasConcept C55493867 @default.
- W2023967548 hasConcept C71924100 @default.
- W2023967548 hasConcept C86803240 @default.
- W2023967548 hasConcept C95444343 @default.
- W2023967548 hasConcept C98274493 @default.
- W2023967548 hasConceptScore W2023967548C126322002 @default.
- W2023967548 hasConceptScore W2023967548C134018914 @default.
- W2023967548 hasConceptScore W2023967548C181199279 @default.
- W2023967548 hasConceptScore W2023967548C185592680 @default.
- W2023967548 hasConceptScore W2023967548C190283241 @default.
- W2023967548 hasConceptScore W2023967548C196795494 @default.
- W2023967548 hasConceptScore W2023967548C2778078955 @default.
- W2023967548 hasConceptScore W2023967548C29311851 @default.
- W2023967548 hasConceptScore W2023967548C502942594 @default.
- W2023967548 hasConceptScore W2023967548C55493867 @default.
- W2023967548 hasConceptScore W2023967548C71924100 @default.
- W2023967548 hasConceptScore W2023967548C86803240 @default.
- W2023967548 hasConceptScore W2023967548C95444343 @default.
- W2023967548 hasConceptScore W2023967548C98274493 @default.
- W2023967548 hasIssue "4" @default.
- W2023967548 hasLocation W20239675481 @default.
- W2023967548 hasOpenAccess W2023967548 @default.
- W2023967548 hasPrimaryLocation W20239675481 @default.
- W2023967548 hasRelatedWork W136745720 @default.
- W2023967548 hasRelatedWork W1978388081 @default.
- W2023967548 hasRelatedWork W2009454127 @default.
- W2023967548 hasRelatedWork W2032738451 @default.
- W2023967548 hasRelatedWork W2205517902 @default.
- W2023967548 hasRelatedWork W2360403394 @default.
- W2023967548 hasRelatedWork W2381393437 @default.
- W2023967548 hasRelatedWork W2384904424 @default.
- W2023967548 hasRelatedWork W2386170955 @default.
- W2023967548 hasRelatedWork W2748952813 @default.
- W2023967548 hasVolume "200" @default.
- W2023967548 isParatext "false" @default.
- W2023967548 isRetracted "false" @default.
- W2023967548 magId "2023967548" @default.
- W2023967548 workType "article" @default.