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- W2023967577 abstract "THE CIRCULATING concentration of free thyroxine indicates, with rare exception, the physiologic status in regard to euthyroidism, hyperthyroidism, or hypothyroidism. Yet only a very small portion (about 0.05%) of the serum total thyroxine exists in this form. The remainder is bound to the thyroxine-binding proteins, notably thyroxine-binding globulin. Measurement of total serum thyroxine (TT 4 ) levels do not necessarily reflect the physiologic status of the patient since an increase or diminution in the binding protein concentration will cause a corresponding change in the serum TT 4 level without affecting either the free thyroxine concentration or the euthyroid state. These same binding-protein changes produce an opposite effect on another test of thyroid function, the triiodothyronine (resin, red blood cell [RBC], or surface adsorbent) uptake test (T 3 uptake). In this test, the free protein-binding sites of the serum compete in the test tube with resin (or RBCs or adsorbent) for added" @default.
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- W2023967577 date "1975-06-09" @default.
- W2023967577 modified "2023-09-25" @default.
- W2023967577 title "Free-Thyroxine Index" @default.
- W2023967577 doi "https://doi.org/10.1001/jama.1975.03250100046029" @default.
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