FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023967578> ?p ?o ?g. }

• W2023967578 endingPage "357" @default.
• W2023967578 startingPage "351" @default.
• W2023967578 abstract "Defensins, antimicrobial and cytotoxic peptides of neutrophils, bind to and are inactivated by blood proteins. We identified defensin interactions with alpha 1-proteinase inhibitor (alpha 1-PI), alpha 1-antichymotrypsin (alpha 1-ACT), alpha 2-antiplasmin (alpha 2-AP), and antithrombin III (AT III) and examined defensin binding to alpha 1-PI and alpha 1-ACT in more detail. Defensin interactions with either alpha 1-PI or alpha 1-ACT were not affected by iodoacetamide or high salt concentration. Preincubation of alpha 1-ACT or alpha 1-PI with increasing concentrations of defensin resulted in a progressive decrease of antiprotease activity of both inhibitors against cathepsin G and antiprotease activity of alpha 1-PI against human neutrophil elastase. At higher concentrations, defensin also ablated the inhibitory effect of normal human serum on cathepsin G and human neutrophil elastase. Both alpha 1-PI and alpha 1-ACT inhibited defensin cytotoxicity toward the human lung carcinoma cell line A549, whereas the elastase inhibitor antileukoprotease did not. Complex interactions between serpins and defensin may have a role in regulating inflammatory processes." @default.
• W2023967578 created "2016-06-24" @default.
• W2023967578 creator A5009227318 @default.
• W2023967578 creator A5022637226 @default.
• W2023967578 creator A5035815172 @default.
• W2023967578 creator A5070208855 @default.
• W2023967578 date "1995-03-01" @default.
• W2023967578 modified "2023-09-25" @default.
• W2023967578 title "Human neutrophil defensin and serpins form complexes and inactivate each other." @default.
• W2023967578 cites W110044107 @default.
• W2023967578 cites W1494805566 @default.
• W2023967578 cites W1516305992 @default.
• W2023967578 cites W1599542520 @default.
• W2023967578 cites W1629982671 @default.
• W2023967578 cites W182155550 @default.
• W2023967578 cites W183757317 @default.
• W2023967578 cites W1907637398 @default.
• W2023967578 cites W1931276869 @default.
• W2023967578 cites W1969254666 @default.
• W2023967578 cites W2024882709 @default.
• W2023967578 cites W2031385566 @default.
• W2023967578 cites W2081917917 @default.
• W2023967578 cites W2104630130 @default.
• W2023967578 cites W2107873069 @default.
• W2023967578 cites W2116725685 @default.
• W2023967578 cites W2140472579 @default.
• W2023967578 cites W2158789628 @default.
• W2023967578 cites W2296584760 @default.
• W2023967578 cites W2327084726 @default.
• W2023967578 cites W2397407438 @default.
• W2023967578 cites W2414844379 @default.
• W2023967578 cites W2482767762 @default.
• W2023967578 cites W2498484671 @default.
• W2023967578 doi "https://doi.org/10.1165/ajrcmb.12.3.7873202" @default.
• W2023967578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7873202" @default.
• W2023967578 hasPublicationYear "1995" @default.
• W2023967578 type Work @default.
• W2023967578 sameAs 2023967578 @default.
• W2023967578 citedByCount "123" @default.
• W2023967578 countsByYear W20239675782012 @default.
• W2023967578 countsByYear W20239675782013 @default.
• W2023967578 countsByYear W20239675782014 @default.
• W2023967578 countsByYear W20239675782015 @default.
• W2023967578 countsByYear W20239675782016 @default.
• W2023967578 countsByYear W20239675782017 @default.
• W2023967578 countsByYear W20239675782018 @default.
• W2023967578 countsByYear W20239675782019 @default.
• W2023967578 countsByYear W20239675782020 @default.
• W2023967578 countsByYear W20239675782021 @default.
• W2023967578 countsByYear W20239675782022 @default.
• W2023967578 crossrefType "journal-article" @default.
• W2023967578 hasAuthorship W2023967578A5009227318 @default.
• W2023967578 hasAuthorship W2023967578A5022637226 @default.
• W2023967578 hasAuthorship W2023967578A5035815172 @default.
• W2023967578 hasAuthorship W2023967578A5070208855 @default.
• W2023967578 hasConcept C109316439 @default.
• W2023967578 hasConcept C129437159 @default.
• W2023967578 hasConcept C153911025 @default.
• W2023967578 hasConcept C159110408 @default.
• W2023967578 hasConcept C181199279 @default.
• W2023967578 hasConcept C185592680 @default.
• W2023967578 hasConcept C202751555 @default.
• W2023967578 hasConcept C203014093 @default.
• W2023967578 hasConcept C2775944032 @default.
• W2023967578 hasConcept C2776317360 @default.
• W2023967578 hasConcept C2776326425 @default.
• W2023967578 hasConcept C2776498113 @default.
• W2023967578 hasConcept C2776914184 @default.
• W2023967578 hasConcept C2777132095 @default.
• W2023967578 hasConcept C2779281246 @default.
• W2023967578 hasConcept C2781044401 @default.
• W2023967578 hasConcept C49453240 @default.
• W2023967578 hasConcept C55493867 @default.
• W2023967578 hasConcept C64943373 @default.
• W2023967578 hasConcept C71924100 @default.
• W2023967578 hasConcept C86803240 @default.
• W2023967578 hasConceptScore W2023967578C109316439 @default.
• W2023967578 hasConceptScore W2023967578C129437159 @default.
• W2023967578 hasConceptScore W2023967578C153911025 @default.
• W2023967578 hasConceptScore W2023967578C159110408 @default.
• W2023967578 hasConceptScore W2023967578C181199279 @default.
• W2023967578 hasConceptScore W2023967578C185592680 @default.
• W2023967578 hasConceptScore W2023967578C202751555 @default.
• W2023967578 hasConceptScore W2023967578C203014093 @default.
• W2023967578 hasConceptScore W2023967578C2775944032 @default.
• W2023967578 hasConceptScore W2023967578C2776317360 @default.
• W2023967578 hasConceptScore W2023967578C2776326425 @default.
• W2023967578 hasConceptScore W2023967578C2776498113 @default.
• W2023967578 hasConceptScore W2023967578C2776914184 @default.
• W2023967578 hasConceptScore W2023967578C2777132095 @default.
• W2023967578 hasConceptScore W2023967578C2779281246 @default.
• W2023967578 hasConceptScore W2023967578C2781044401 @default.
• W2023967578 hasConceptScore W2023967578C49453240 @default.
• W2023967578 hasConceptScore W2023967578C55493867 @default.
• W2023967578 hasConceptScore W2023967578C64943373 @default.
• W2023967578 hasConceptScore W2023967578C71924100 @default.
• W2023967578 hasConceptScore W2023967578C86803240 @default.
• W2023967578 hasIssue "3" @default.

• next