Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023967584> ?p ?o ?g. }
- W2023967584 endingPage "1105" @default.
- W2023967584 startingPage "1096" @default.
- W2023967584 abstract "Successful ovulation and implantation processes play a crucial role in female fertility. Adamts-1, a matrix metalloproteinase with disintegrin and thrombospondin motifs, has been suggested to be regulated by the progesterone receptor in the hormonal pathway leading to ovulation. With the primary aim of investigating the role of Adamts-1 in female fertility, we generated Adamts-1 null mice. Forty-five percent of the newborn Adamts-1 null mice die, with death most likely caused by a kidney malformation that becomes apparent at birth. Surviving female null mice were subfertile, whereas males reproduced normally. Ovulation in null females was impaired because of mature oocytes remaining trapped in ovarian follicles. No uterine phenotype was apparent in Adamts-1 null animals. Embryo implantation occurred normally, the uteri were capable of undergoing decidualization, and no morphological changes were observed. These results demonstrate that a functional Adamts-1 is required for normal ovulation to occur, and hence the Adamts-1 gene plays an important role in female fertility, primarily during the tissue remodeling process of ovulation." @default.
- W2023967584 created "2016-06-24" @default.
- W2023967584 creator A5007839058 @default.
- W2023967584 creator A5034108848 @default.
- W2023967584 creator A5035018866 @default.
- W2023967584 creator A5042601651 @default.
- W2023967584 creator A5045862314 @default.
- W2023967584 creator A5047753337 @default.
- W2023967584 creator A5047890725 @default.
- W2023967584 creator A5056657507 @default.
- W2023967584 date "2004-04-01" @default.
- W2023967584 modified "2023-10-15" @default.
- W2023967584 title "Adamts-1 Is Essential for the Development and Function of the Urogenital System1" @default.
- W2023967584 cites W1503337666 @default.
- W2023967584 cites W1893337122 @default.
- W2023967584 cites W1964849541 @default.
- W2023967584 cites W1966361056 @default.
- W2023967584 cites W1966582299 @default.
- W2023967584 cites W1968574939 @default.
- W2023967584 cites W1970118949 @default.
- W2023967584 cites W1976384802 @default.
- W2023967584 cites W2016411107 @default.
- W2023967584 cites W2016484384 @default.
- W2023967584 cites W2016984261 @default.
- W2023967584 cites W2018028560 @default.
- W2023967584 cites W2028289405 @default.
- W2023967584 cites W2032712201 @default.
- W2023967584 cites W2036842448 @default.
- W2023967584 cites W2042589651 @default.
- W2023967584 cites W2047083811 @default.
- W2023967584 cites W2048724646 @default.
- W2023967584 cites W2066664707 @default.
- W2023967584 cites W2068505754 @default.
- W2023967584 cites W2070882725 @default.
- W2023967584 cites W2074881372 @default.
- W2023967584 cites W2076812625 @default.
- W2023967584 cites W2082144373 @default.
- W2023967584 cites W2082559087 @default.
- W2023967584 cites W2096654038 @default.
- W2023967584 cites W2109276727 @default.
- W2023967584 cites W2115410748 @default.
- W2023967584 cites W2116013040 @default.
- W2023967584 cites W2116761578 @default.
- W2023967584 cites W2119445810 @default.
- W2023967584 cites W2120892175 @default.
- W2023967584 cites W2121535505 @default.
- W2023967584 cites W2123811141 @default.
- W2023967584 cites W2133865055 @default.
- W2023967584 cites W2149224534 @default.
- W2023967584 doi "https://doi.org/10.1095/biolreprod.103.023911" @default.
- W2023967584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14668204" @default.
- W2023967584 hasPublicationYear "2004" @default.
- W2023967584 type Work @default.
- W2023967584 sameAs 2023967584 @default.
- W2023967584 citedByCount "167" @default.
- W2023967584 countsByYear W20239675842012 @default.
- W2023967584 countsByYear W20239675842013 @default.
- W2023967584 countsByYear W20239675842014 @default.
- W2023967584 countsByYear W20239675842015 @default.
- W2023967584 countsByYear W20239675842016 @default.
- W2023967584 countsByYear W20239675842017 @default.
- W2023967584 countsByYear W20239675842018 @default.
- W2023967584 countsByYear W20239675842019 @default.
- W2023967584 countsByYear W20239675842020 @default.
- W2023967584 countsByYear W20239675842021 @default.
- W2023967584 countsByYear W20239675842022 @default.
- W2023967584 countsByYear W20239675842023 @default.
- W2023967584 crossrefType "journal-article" @default.
- W2023967584 hasAuthorship W2023967584A5007839058 @default.
- W2023967584 hasAuthorship W2023967584A5034108848 @default.
- W2023967584 hasAuthorship W2023967584A5035018866 @default.
- W2023967584 hasAuthorship W2023967584A5042601651 @default.
- W2023967584 hasAuthorship W2023967584A5045862314 @default.
- W2023967584 hasAuthorship W2023967584A5047753337 @default.
- W2023967584 hasAuthorship W2023967584A5047890725 @default.
- W2023967584 hasAuthorship W2023967584A5056657507 @default.
- W2023967584 hasBestOaLocation W20239675841 @default.
- W2023967584 hasConcept C109523444 @default.
- W2023967584 hasConcept C126322002 @default.
- W2023967584 hasConcept C134018914 @default.
- W2023967584 hasConcept C16685009 @default.
- W2023967584 hasConcept C167814343 @default.
- W2023967584 hasConcept C196843134 @default.
- W2023967584 hasConcept C2776224515 @default.
- W2023967584 hasConcept C2777702977 @default.
- W2023967584 hasConcept C2778316770 @default.
- W2023967584 hasConcept C2779066055 @default.
- W2023967584 hasConcept C54355233 @default.
- W2023967584 hasConcept C55728118 @default.
- W2023967584 hasConcept C71315377 @default.
- W2023967584 hasConcept C71924100 @default.
- W2023967584 hasConcept C86803240 @default.
- W2023967584 hasConcept C95444343 @default.
- W2023967584 hasConceptScore W2023967584C109523444 @default.
- W2023967584 hasConceptScore W2023967584C126322002 @default.
- W2023967584 hasConceptScore W2023967584C134018914 @default.
- W2023967584 hasConceptScore W2023967584C16685009 @default.
- W2023967584 hasConceptScore W2023967584C167814343 @default.